Pathophysiology of mesenteric ischemia/reperfusion: a review.

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCerqueira, Nereide Freire
dc.creatorHussni, Carlos Alberto
dc.creatorYoshida, Winston Bonetti
dc.date2014-05-27T11:21:22Z
dc.date2016-10-25T18:20:53Z
dc.date2014-05-27T11:21:22Z
dc.date2016-10-25T18:20:53Z
dc.date2005-07-01
dc.date.accessioned2017-04-06T01:13:47Z
dc.date.available2017-04-06T01:13:47Z
dc.identifierActa cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia., v. 20, n. 4, p. 336-343, 2005.
dc.identifier0102-8650
dc.identifierhttp://hdl.handle.net/11449/68306
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68306
dc.identifier10.1590/S0102-86502005000400013
dc.identifierS0102-86502005000400013
dc.identifier2-s2.0-33645895309.pdf
dc.identifier2-s2.0-33645895309
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502005000400013
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889660
dc.descriptionDuring ischemia, the cell structures are progressively damaged, but restoration of the blood flow, paradoxically, intensifies the lesions caused by the ischemia. The mechanisms of ischemia injury and reperfusion (I/R) have not been completely defined and many studies have been realized in an attempt to find an ideal therapy for mesenteric I/R. The occlusion and reperfusion of the splanchnic arteries provokes local and systemic alterations principally derived from the release of cytotoxic substances and the interaction between neutrophils and endothelial cells. Substances involved in the process are discussed in the present review, like oxygen-derived free radicals, nitric oxide, transcription factors, complement system, serotonin and pancreatic proteases. The mechanisms of apoptosis, alterations in other organs, therapeutic and evaluation methods are also discussed.
dc.languageeng
dc.relationActa Cirúrgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectreactive oxygen metabolite
dc.subjecthuman
dc.subjectintestine
dc.subjectischemia
dc.subjectmesentery
dc.subjectpathology
dc.subjectpathophysiology
dc.subjectperitoneal disease
dc.subjectreperfusion injury
dc.subjectreview
dc.subjectvascularization
dc.subjectHumans
dc.subjectIntestines
dc.subjectIschemia
dc.subjectMesentery
dc.subjectPeritoneal Diseases
dc.subjectReactive Oxygen Species
dc.subjectReperfusion Injury
dc.titlePathophysiology of mesenteric ischemia/reperfusion: a review.
dc.typeOtro


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