Genetic, sociodemographic and lifestyle factors associated with serum 25-hydroxyvitamin D concentrations in Brazilian adults: the Pró-Saúde Study

Fatores genéticos, sociodemográficos e de estilo de vida nas concentrações séricas de 25-hidroxivitamina D em adultos brasileiros: o Estudo Pró-Saúde;
Factores genéticos, sociodemográficos y estilo de vida asociados con la concentración sérica 25-hidroxivitamina D en adultos brasileños: Estudio Pro-Salud

dc.creatorBezerra, Flávia Fioruci
dc.creatorNormando, Paula
dc.creatorFonseca, Ana Carolina P.
dc.creatorZembrzuski, Verônica
dc.creatorCampos Junior, Mario
dc.creatorCabello-Acero, Pedro Hernan
dc.creatorFaerstein, Eduardo
dc.date2022-08-15T11:36:03Z
dc.date2022-08-15T11:36:03Z
dc.date2022
dc.date.accessioned2023-09-27T00:00:36Z
dc.date.available2023-09-27T00:00:36Z
dc.identifierBEZERRA, Flávia Fioruci et al. Genetic, sociodemographic and lifestyle factors associated with serum 25-hydroxyvitamin D concentrations in Brazilian adults: the Pró-Saúde Study. Cadernos de Saúde Pública, Rio de Janeiro, v. 38, n. 1, e00287820, 2022.
dc.identifier0102-311X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/54637
dc.identifier10.1590/0102-311X00287820
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8896497
dc.descriptionThis study aims to investigate factors associated with serum 25-hydroxyvitamin D [25(OH)D] concentration in Brazilian adults considering sociodemographic and lifestyle factors, as well as vitamin D-related single nucleotide polymorphisms (SNPs). This is a cross-sectional study (n = 491; 34-79y; 251 women), nested within a prospective cohort (Pró-Saúde Study). Associations between serum 25(OH)D and sociodemographic characteristics, diet, use of supplement, physical activity, season of blood collection, body fat, skin type, sun exposure index, and SNPs CYP2R1-rs10741657 and GC-rs2282679 were explored by multiple linear regression. The prevalence of serum 25(OH)D < 50nmol/L was 55%. Serum 25(OH)D was lower among women (β = -4.38; 95%CI: -8.02; -0.74), those with higher visceral fat (β = -4.02; 95%CI: -5.92; -2.12), and those with AC and CC genotypes for GC-rs2282679 (β = -6.84; 95%CI: -10.09; -3.59; β = -10.63; 95%CI: -17.52; -3.74, respectively). Factors directly associated with serum 25(OH)D included summer (β = 20.14; 95%CI: 14.38; 25.90), intermediate skin type (β = 6.16; 95%CI: 2.52; 9.80), higher sun exposure (β = 0.49; 95%CI: 0.22; 0.75), vitamin D intake (β = 0.48; 95%CI: 0.03; 0.93), and physical activity (β = 4.65; 95%CI: 1.54; 7.76). Besides physical activity, diet, and sun exposure, non-modifiable factors, such as GC genotypes must be considered when evaluating vitamin D insufficiency in mixed-race populations. Moreover, high visceral fat in association with poorer vitamin D status deserve attention given that both conditions are unfavorably related with chronic and acute health outcomes.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca.
dc.rightsopen access
dc.subjectVitamina D
dc.subjectPolimorfismo de nucleotídeo único
dc.subjectGordura Visceral
dc.subjectPigmentação da pele
dc.subjectVitamin D
dc.subjectSingle Nucleotide Polymorphism
dc.subjectVisceral Fat
dc.subjectSkin Pigmentation
dc.titleGenetic, sociodemographic and lifestyle factors associated with serum 25-hydroxyvitamin D concentrations in Brazilian adults: the Pró-Saúde Study
dc.titleFatores genéticos, sociodemográficos e de estilo de vida nas concentrações séricas de 25-hidroxivitamina D em adultos brasileiros: o Estudo Pró-Saúde
dc.titleFactores genéticos, sociodemográficos y estilo de vida asociados con la concentración sérica 25-hidroxivitamina D en adultos brasileños: Estudio Pro-Salud
dc.typeArticle


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