Trypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice

dc.creatorOlivieri, Bianca P.
dc.creatorSouza, Andréa P. de
dc.creatorAlmeida, Vinícius Cotta de
dc.creatorCastro, Solange L. de
dc.creatorAraujo-Jorge, Tania C.
dc.date2020-01-29T15:06:28Z
dc.date2020-01-29T15:06:28Z
dc.date2006
dc.date.accessioned2023-09-26T23:59:02Z
dc.date.available2023-09-26T23:59:02Z
dc.identifierOLIVIERI, Bianca P. et al. Trypanosoma cruzi: Alterationm in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice. Experimental Parasitology, v. 114, p. 228-234, 2006.
dc.identifier0014-4894
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/39585
dc.identifier10.1016/j.exppara.2006.02.020
dc.identifier1090-2449
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8896224
dc.descriptionDisability and mortality as consequence of Chagas disease is enormous in South America. Recently, the success of the trypanocidal treatment with benznidazole, the only available drug, has been associated with the host immune response. In the current study, the impact of benznidazole administration immediately after the experimental infection with Trypanosoma cruzi was evaluated in the main lymphocyte populations in lymphoid organs. Untreated mice displayed enlargement of spleen and lymph node related to the increased frequency of T and B lymphocytes, respectively. An intense thymus involution with the depletion of CD4(+)CD8(+) double-positive thymocytes also occurred. Benznidazole treatment led to a partial reversion of the spleen and lymph node enlargement related to changes in the frequency of lymphocyte subsets due to infection. Prevention of thymus involution was achieved, with the profile of thymocyte subsets similar to that of non-infected mice. The parasitic load at the onset of T. cruzi infection seems critical to trigger immune system activation.
dc.description2025-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier 12 Months
dc.rightsrestricted access
dc.subjectTrypanosma cruzi
dc.subjectBenznidazole
dc.subjectRatos
dc.subjectÓrgãos linfóides
dc.subjectBenznidazol
dc.subjectCamundongos não infectados e não tratados
dc.subjectCamundongos não infectados e tratados com benznidazol
dc.subjectCamundongos infectados e não tratados
dc.subjectCamundongos infectados e tratados com benznidazol
dc.subjectDias após a infecção
dc.subjectTrypanosma cruzi
dc.subjectLymphoid organs
dc.subjectMice
dc.subjectBenznidazole
dc.subjectN, non-infected and non treated mice
dc.subjectNBz-Non- infected and benznidazole treated mice
dc.subjectI-infected and non-treated mice
dc.subjectIBz, infected and benznidazole-treated mice
dc.subjectDpi, days post-infection
dc.titleTrypanosoma cruzi: alteration in the lymphoid compartments following interruption of infection by early acute benznidazole therapy in mice
dc.typeArticle


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