HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil.

dc.creatorSilva, Edinete Melo da
dc.creatorAcosta, Angelina Xavier
dc.creatorSantos, Eduardo José Melo
dc.creatorMartins Netto, Eduardo
dc.creatorLemaire, Denise Carneiro
dc.creatorOliveira, Adriano Silva
dc.creatorBarbosa, Carolina Matos
dc.creatorBendicho, Maria Teresita
dc.creatorCastro Filho, Bernardo Galvão
dc.creatorBrites, Carlos
dc.date2014-07-25T19:35:44Z
dc.date2014-07-25T19:35:44Z
dc.date2010
dc.date.accessioned2023-09-26T23:58:42Z
dc.date.available2023-09-26T23:58:42Z
dc.identifierSILVA, E. M. et al. HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil. Brazilian Journal of Infectious Disease, v. 14, n. 5, p. 468-475, 2010.
dc.identifier1678-4391
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8086
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8896172
dc.descriptionUNLABELLED: Host genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. OBJECTIVE: To evaluate the association between serological epitopes HLA-Bw4 and HLA-Bw6 and prognostic markers in AIDS. METHODS: 147 HIV-infected individuals in Bahia, Northeast Brazil, were genotyped for HLA class I locus. HLA class I genotyping was performed by hybridization with sequence-specific oligonucleotide probes following amplification of the corresponding HLA-A, HLA-B and HLA-C genes. Statistical analysis was performed using Fisher's exact and ANOVA tests for categorical and continuous variables, respectively. RESULTS: We detected a significant association (χ2 = 4.856; p = 0.018) between the presence of HLA-Bw4 and low levels of viremia. Eighteen out of the 147 HIV-infected individuals presented viremia <1,800 copies/mL and 129 presented viremia > 2,000 copies/mL. Ninety and four percent (17/18) of all individuals with viremia < 1,800 copies/mL carried HLA-Bw4, compared to 67.4% (87/129) of individuals with viremia > 2,000 copies/mL. Additionally, we found a significantly higher frequency of B*57 (OR = 13.94; 95% CI = 4.19-46.38; p < 0.0001) and Cw*18 (OR = 16.15; 95% CI = 3.46-75.43; p < 0.0001) alleles, favoring the group with lower viremia levels, in comparison with those with higher viral load. CONCLUSION: HLA-Bw4-B*57 and Cw*18 alleles are associated with lower level of viral load in HIV-infected Brazilian patients. These findings may help us in understanding the determinants of HIV evolution in Brazilian patients, as well as in providing important information on immune response correlates of protection for such population
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectHIV
dc.subjectAids
dc.subjectMHC
dc.subjectHLA
dc.subjectPolymorphism
dc.subjectInfecções por HIV/virologia
dc.subjectHIV-1/genética
dc.subjectAntígenos HLA-B/sangue
dc.subjectViremia/sangue
dc.subjectAdulto
dc.subjectIdoso
dc.subjectAlelos
dc.subjectContagem de Linfócito CD4
dc.subjectProgressão da Doença
dc.subjectFeminino
dc.subjectMarcadores Genéticos
dc.subjectGenótipo
dc.subjectInfecções por HIV/sangue
dc.subjectHIV-1/imunologia
dc.subjectHumanos
dc.subjectMasculino
dc.subjectMeia-Idade
dc.subjectPrognóstico
dc.subjectCarga Viral
dc.subjectAdulto Jovem
dc.titleHLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation in HIV-1 infected individuals in Salvador, Brazil.
dc.typeArticle


Este ítem pertenece a la siguiente institución