Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis

dc.creatorBittencourt, Achilea Candida Lisboa
dc.creatorFreitas, Luiz Antonio Rodrigues de
dc.creatorPompeu, Margarida Maria de Lima
dc.creatorVieira, Maria Lucia
dc.creatorBarral, Aldina Maria Prado
dc.date2014-07-10T17:47:54Z
dc.date2014-07-10T17:47:54Z
dc.date1990
dc.date.accessioned2023-09-26T23:58:26Z
dc.date.available2023-09-26T23:58:26Z
dc.identifierBITTENCOURT, Achilea Candida Lisboa et al. Distinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 1, p. 53-59, 1990.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7910
dc.identifier10.1590/S0074-02761990000100008
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8896125
dc.descriptionThe authors investigated the relation between parasites and host-cells in active and regressed lesions of a patient with diffuse cutaneous leishmaniasis, evaluating the frequency of different cell types, and the location and integrity of amastigotes. No correlation was found between parasite integrity and size of parasitophorous vacuoles. They observed ultrastructural findings characterizing a cell mediated immune response: macrophages lysis, parasitic destruction inside macrophages, close contact between parasitized macrophages and lymphocytes and between parasites and lymphocytes, lymphocytic infiltration and fibrosis. They suggest that in DCL there is a limited cellular immune response, although insufficient to control infection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFiocruz
dc.rightsopen access
dc.subjectDiffuse cutaneous leishmaniasis
dc.subjectHuman leishmaniasis
dc.subjectLeishmania
dc.subjectSkin biopsie
dc.subjectLeishmaniose/patologia
dc.subjectPele/ultraestrutura
dc.subjectAdulto
dc.subjectAnimais
dc.subjectBiópsia
dc.subjectHumanos
dc.subjectLeishmania/isolamento & purificação
dc.subjectLeishmaniose/parasitologia
dc.subjectMacrófagos/parasitologia
dc.subjectMacrófagos/ultraestrutura
dc.subjectMasculino
dc.titleDistinct ultrastructural aspects in different biopsies of a single patient with diffuse cutaneous leishmaniasis
dc.typeArticle


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