Hepatitis B Virus Genotype D: an Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics

dc.creatorSant’Anna, Thaís B.
dc.creatorAraujo, Natalia M.
dc.date2023-04-29T15:03:59Z
dc.date2023-04-29T15:03:59Z
dc.date2023
dc.date.accessioned2023-09-26T23:58:14Z
dc.date.available2023-09-26T23:58:14Z
dc.identifierSANT´Anna, Thaís B.; ARAUJO, Natalia M. Hepatitis B Virus Genotype D: an Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics. Microorganisms, v. 11, 1101, p. 1-14, Apr. 2023.
dc.identifier2076-2607
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/58085
dc.identifier10.3390/ microorganisms11051101
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8896091
dc.descriptionThe hepatitis B virus (HBV) genotype D (HBV/D) is the most extensively distributed genotype worldwide with distinct molecular and epidemiological features. This report provides an up-to-date review on the history of HBV/D subgenotyping and misclassifications, along with largescale analysis of over 1000 HBV/D complete genome sequences, with the aim of gaining a thorough understanding of the global prevalence and geographic distribution of HBV/D subgenotypes. We have additionally explored recent paleogenomic findings, which facilitated the detection of HBV/D genomes dating back to the late Iron Age and provided new perspectives on the origins of modern HBV/D strains. Finally, reports on distinct disease outcomes and responses to antiviral therapy among HBV/D subgenotypes are discussed, further highlighting the complexity of this genotype and the importance of HBV subgenotyping in the management and treatment of hepatitis B.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectVírus da Hepatite B
dc.subjectGenótipo D
dc.subjectSubgenótipos
dc.subjectDistribuição geográfica
dc.subjectMutações
dc.subjectEvolução
dc.subjectHepatitis B virus
dc.subjectGenotype D
dc.subjectSubgenotypes
dc.subjectGeographic distribution
dc.subjectMutations
dc.subjectEvolution
dc.titleHepatitis B Virus Genotype D: an Overview of Molecular Epidemiology, Evolutionary History, and Clinical Characteristics
dc.typeArticle


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