Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.

dc.creatorCampos, José Humberto O
dc.creatorGomes, Heitor Carvalho
dc.creatordosSantos, Washington Luis Conrado
dc.creatorCardeal, Mauricio
dc.creatorFerreira, Lydia Masako
dc.date2014-05-23T19:30:15Z
dc.date2014-05-23T19:30:15Z
dc.date2008
dc.date.accessioned2023-09-26T23:57:34Z
dc.date.available2023-09-26T23:57:34Z
dc.identifierCAMPOS, J. H. O. et al. Effect of nicotine treatment and withdrawal on random-pattern skin flaps in rats. Experimental and Toxicologic Pathology, v. 60, p. 449–452, 2008.
dc.identifier0940-2993
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/7652
dc.identifier:10.1016/j.etp.2008.02.004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8896000
dc.descriptionBackground: Tobacco use is associated with a high incidence of skin necrosis after surgery. The ideal timing for the cessation of tobacco use before plastic surgery has not, however, been precisely determined. The aim of this work was to define the ideal duration of nicotine withdrawal prior to random-pattern skin flap surgery in rats. Methods: Groups of 11 animals were subcutaneously injected with saline or nicotine (2 mg/kg) twice a day and subjected to random-pattern skin flap surgery according to the following protocol: Group I: continuously injected with saline 4 weeks before and 1 week after the surgery; Group II: injected with nicotine for 4 weeks until the day of the surgery; Group III: injected with nicotine for 4 weeks until one day before the surgery; Group IV: injected with nicotine for 4 weeks until 5 days before the surgery; Group V: injected with nicotine for 4 weeks until 10 days before the surgery; Group VI: continuously injected with nicotine for 4 weeks before and 1 week after the surgery. McFARLANE skin flaps were performed on the dorsal skin, and the rats were sacrificed 1 week after the surgery. Results: The necrotic area was smaller in group I (8.85 cm2) than in group II (12.15 cm2), III (12.88 cm2) and VI (14.84 cm2) (ANOVA po0.0001). There was no difference between groups I, IV (10.13 cm2) and V (9.27 cm2). Conclusions: In conclusion, 5 days before surgery was considered the ideal time for nicotine withdrawal in this experimental model.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectNicotine
dc.subjectMcFARLANE skin flaps
dc.subjectNecrosis
dc.subjectTobacco
dc.subjectRats
dc.subjectNicotina/toxicidade
dc.subjectAgonistas Nicotínicos/toxicidade
dc.subjectPele/efeitos de drogas
dc.subjectRetalhos Cirúrgicos
dc.subjectSobrevivência de Tecidos/efeitos de drogas
dc.subjectAnimais
dc.subjectModelos Animais de Doenças
dc.subjectEsquema de Medicação
dc.subjectInjeções Subcutâneas
dc.subjectNecrose
dc.subjectNicotina/administração & dosagem
dc.subjectAgonistas Nicotínicos/administração & dosagem
dc.subjectRatos
dc.subjectPele/patologia
dc.subjectRetalhos Cirúrgicos/patologia
dc.subjectSuspensão de Tratamento
dc.titleEffect of nicotine treatment and withdrawal on random-pattern skin flaps in rats.
dc.typeArticle


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