Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse

dc.creatorLima, Camila Bião
dc.creatorIglesias, Karen Brasil
dc.creatorAndrade, Zilton de Araújo
dc.date2011-08-21T00:02:13Z
dc.date2011-08-21T00:02:13Z
dc.date2007
dc.date.accessioned2023-09-26T23:57:05Z
dc.date.available2023-09-26T23:57:05Z
dc.identifierLIMA, C. B. et al. Thalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse. Memórias do Instituto Oswaldo Cruz, v. 102, n. 7, p. 883-885, Nov. 2007
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/2805
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8895927
dc.descriptionPapes III - Fiocruz, Pronex
dc.descriptionThe relationship between angiogenesis and fibrosis has been demonstrated in several pathological conditions, one of them being schistosomiasis. To observe whether suppression of angiogenesis would interfere with fibrosis, Thalidomide, an anti-angiogenesis drug, was administered during 30 consecutive days to mice with experimental schistosomiasis. Computerized morphometric measurements of fibrosis, and the counting of blood vessels from hepatic schistosomal lesions did not significantly differ when treated animals and their controls were compared at the end of the experiments. These rather unexpected results are presented under the understanding that they may be of interest during further studies on the anti-angiogenesis properties of thalidomide, and the relationship between angiogenesis and fibrosis
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectThalidomide
dc.subjectSchistosomiasis
dc.subjectAngiogenesis
dc.subjectFibrosis
dc.subjectInibidores da Angiogênese
dc.subjectCirrose Hepática
dc.subjectNeovascularização Patológica
dc.subjectEsquistossomose mansoni
dc.subjectFígado
dc.subjectModelos Animais de Doenças
dc.subjectCamundongos
dc.titleThalidomide failed to inhibit angiogenesis and fibrosis in hepatic schistosomiasis of the mouse
dc.typeArticle


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