dc.creatorRodrigues, Rosana Souza
dc.creatorRibeiro, Gabriel Motta
dc.creatorBarreto, Miriam Menna
dc.creatorZin, Walter Araujo
dc.creatorMendes, Júlia de Toledo
dc.creatorMartins, Philippe Alcantara G.
dc.creatorAlmeida, Sergio Altino de
dc.creatorBasílio, Rodrigo
dc.creatorGonçalves, Remy Martins
dc.creatorHotz, Eugênio Damaceno
dc.creatorBozza, Patricia T.
dc.creatorBozza, Fernando A.
dc.creatorCarvalho, Alysson Roncally Silva
dc.creatorCastro, Paulo Henrique Rosado de
dc.date2022-12-04T20:59:16Z
dc.date2022-12-04T20:59:16Z
dc.date2022
dc.date.accessioned2023-09-26T23:56:54Z
dc.date.available2023-09-26T23:56:54Z
dc.identifierRODRIGUES, Rosana Souza et al. Increased Lung Immune Metabolic Activity in COVID-19 Survivors. Clinical Nuclear Medicine, v. 47, n. 12, p. 1 - 7, Dec. 2022.
dc.identifier1536-0229
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/55889
dc.identifier10.1097/RLU.0000000000004376
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8895892
dc.descriptionPurpose: We quantified lung glycolytic metabolic activity, clinical symptoms and inflammation, coagulation, and endothelial activation biomarkers in 2019 coronavirus disease (COVID-19) pneumonia survivors. Methods: Adults previously hospitalized with moderate to severe COVID-19 pneumonia were prospectively included. Subjects filled out a questionnaire on clinical consequences, underwent chest CTand 18F-FDG PET/CT, and provided blood samples on the same day. Forty-five volunteers served as control subjects. Analysis of CTimages and quantitative voxel-based analysis of PET/CTimages were performed for both groups. 18F-FDGuptake in thewhole-lung volume and in high- and low-attenuation areaswas calculated and normalized to liver values. Quantification of plasma markers of inflammation (interleukin 6), D-dimer, and endothelial cell activation (angiopoietins 1 and 2, vascular cell adhesion molecule 1, and intercellular adhesion molecule 1) was also performed. Results: We enrolled 53 COVID-19 survivors (62.3% were male; median age, 50 years). All survivors reported at least 1 persistent symptom, and 41.5% reported more than 6 symptoms. The mean lung density was greater in survivors than in control subjects, and more metabolic activity was observed in normal and dense lung areas, even months after symptom onset. Plasma proinflammatory proinflammatory, coagulation, and endothelial activation biomarker concentrations were also significantly higher in survivors. Conclusion:We observed more metabolic activity in areas of high and normal lung attenuation several months after moderate to severe COVID-19 pneumonia. In addition, plasma markers of thromboinflammation and endothelial activation persisted. These findings may have implications for our understanding of the in vivo pathogenesis and long-lasting effects of COVID-19 pneumonia.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWolters Kluwer Health, Inc
dc.rightsopen access
dc.subjectCOVID-19
dc.subjectPneumonia
dc.subjectAtivação de células endoteliais
dc.subjectImunometabolismo
dc.subjectCOVID longa
dc.subjectPET/CT
dc.subjectInflamação pulmonar
dc.subjectCOVID-19
dc.subjectPneumonia
dc.subjectEndothelial cell activation
dc.subjectImmunometabolism
dc.subjectlong COVID
dc.subjectPET/CT
dc.subjectPulmonary inflammation
dc.titleIncreased Lung Immune Metabolic Activity in COVID-19 Survivors
dc.typeArticle


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