Social conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil

dc.creatorSampaio, Aletheia Soares
dc.creatorVasconcelos, Ana Lúcia Ribeiro de
dc.creatorMorais, Clarice Neuenschwander Lins de
dc.creatorDiniz, George Tadeu Nunes
dc.creatorFigueiredo, Anna Lígia de Castro
dc.creatorMontenegro, Sílvia Maria Lucena
dc.date2019-05-14T16:07:10Z
dc.date2019-05-14T16:07:10Z
dc.date2018
dc.date.accessioned2023-09-26T23:56:05Z
dc.date.available2023-09-26T23:56:05Z
dc.identifierSAMPAIO, Aletheia Soares et al. Social Conditions and Immune Response in Human Immunodeficiency Virus-Seropositive Pregnant Women: A Cross-Sectional Study in Brazil. Revista da Sociedade Brasileira de Medicina Tropical, v. 51, n. 1, p. 21–29, fev. 2018.
dc.identifier1678-9849
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/33067
dc.identifier10.1590/0037-8682-0107-2017
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8895750
dc.descriptionStrategic Program to Support Research in Health (PAPES VI), National Council for Technological and Scientific Development, Oswaldo Cruz Foundation, 407.650/2012-1.
dc.descriptionThe functioning of the immune system during pregnancy is altered in both human immunodeficiency virus (HIV)-infected and uninfected women. Unfavorable socioeconomic conditions have been indicative of higher morbidity and mortality and worsening of the immune system. The aim of this study was to correlate social status with levels of interleukin (IL)-10 (non-inflammatory) and interferon-gamma (IFN-γ; inflammatory) cytokines. METHODS: A cross-sectional study was conducted with three groups of women: 33 pregnant HIV-infected (G1); 40 non-pregnant, HIV-infected (G2); and 35 pregnant, HIV-uninfected. To measure the social status, a compound indicator called the social status index (SSI), was established using sociodemographic variables (i.e., education level, housing conditions, per capita income, and habitation and sanitary conditions). RESULTS: The HIV-infected women had a higher proportion of unfavorable SSI (73% and 75% of G1 and G2, respectively). There were significantly lower IL-10 levels in the G1 group with both unfavorable and favorable SSI than in the other groups. No significant difference in IFN-γ levels was observed among groups. However, the G1 group had higher IFN-γ values among both favorable and unfavorable SSI groups. CONCLUSIONS: Higher rates of unfavorable conditions, including lower education levels, IL-10 levels, and a trend for higher IFN-γ levels, were identified among HIV-infected women, pregnant and non-pregnant. These factors may interfere in health care and lead to poor outcomes during pregnancy. Therefore, we suggest that health policies could be created to specifically address these factors in this population.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectAcquired immunodeficiency syndrome
dc.subjectPregnancy
dc.subjectPoverty
dc.subjectInterleukin-10
dc.subjectAdulto
dc.subjectBrasil
dc.subjectEstudos Transversais
dc.subjectFêmea
dc.subjectInfecções por HIV / sangue
dc.subjectInfecções por HIV / imunologia
dc.subjectHumanos
dc.subjectInterferon gama / sangue
dc.subjectInterferon gama / imunologia
dc.subjectInterleucina-10 / sangue
dc.subjectInterleucina-10 / imunologia
dc.subjectGravidez
dc.subjectComplicações na Gravidez Infecciosa / sangue
dc.subjectComplicações na Gravidez Infecciosa / imunologia
dc.subjectComplicações na Gravidez Infecciosa / virologia
dc.subjectCondições sociais
dc.subjectFatores Socioeconômicos
dc.titleSocial conditions and immune response in human immunodeficiency virus-seropositive pregnant women: a cross-sectional study in Brazil
dc.typeArticle


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