Developing T-cell migration: role of semaphorins and ephrins

dc.creatorCruz, Daniella Arêas Mendes da
dc.creatorStimamiglio, Marco Augusto
dc.creatorMuñoz, Juan Jose
dc.creatorAlfaro, David
dc.creatorTerra-Granado, Eugênia
dc.creatorGarcia-Ceca, Javier
dc.creatorAlonso-Colmenar, Luis Miguel
dc.creatorSavino, Wilson
dc.creatorZapata, Agustin G.
dc.date2017-06-19T17:05:18Z
dc.date2017-06-19T17:05:18Z
dc.date2012
dc.date.accessioned2023-09-26T23:55:42Z
dc.date.available2023-09-26T23:55:42Z
dc.identifierCRUZ, Daniela Arêas Mendes da; et al. Developing T-cell migration: role of semaphorins and ephrins. The FASEB Journal, v.26, n.11 ,p:4390-4399, 2012.
dc.identifier0892-6638
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/19406
dc.identifier10.1096/fj.11-202952
dc.identifier1530-6860
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8895686
dc.descriptionCell migration is a crucial event for normal T-cell development, and various ligand/receptor pairs have been implicated. Most of them, including chemokines and extracellular matrix proteins, have attractant properties on thymocytes. We discuss herein two further groups of ligand/receptor pairs, semaphorins/neuropilins and ephs/ephrins, which are constitutively expressed by thymocytes and thymic microenvironmental cells. Evidence shows that the corresponding interactions are relevant for developing T-cell migration, including the entry of bone marrow progenitor cells, migration of CD4/CD8-defined thymocyte subpopulations triggered by chemokines and/or extracellular matrix proteins, and thymocyte export. Conceptually, the data summarized here show that thymocyte migration results from a complex network of molecular interactions, which generate not only attraction, but also repulsion of migrating T-cell precursors.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherFederation of American Society of Experimental Biology
dc.rightsrestricted access
dc.subjectCélulas epiteliais tímicas
dc.subjectTimo
dc.subjectMigração de timócitos
dc.subjectNeuropilinas
dc.subjectthymus
dc.subjectthymic epithelial cells
dc.subjectthymocyte migration
dc.subjectneuropilins
dc.subjectephs
dc.titleDeveloping T-cell migration: role of semaphorins and ephrins
dc.typeArticle


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