Effect of Physical Exercise Training in Patients With Chagas Heart Disease (from the PEACH STUDY)

dc.creatorMendes, Fernanda Souza Nogueira Sardinha
dc.creatorMediano, Mauro Felippe Felix
dc.creatorSouza, Fernando Cesar Castro
dc.creatorSilva, Paula Simplício
dc.creatorCarneiro, Fernanda Martins
dc.creatorHolanda, Marcelo Teixeira
dc.creatorSaraiva, Roberto Magalhães
dc.creatorXavier, Sergio Salles
dc.creatorBrasil, Pedro Emmanuel Alvarenga Americano do
dc.creatorSousa, Andréa Silvestre
dc.date2020-05-14T21:30:52Z
dc.date2020-05-14T21:30:52Z
dc.date2020
dc.date.accessioned2023-09-26T23:55:35Z
dc.date.available2023-09-26T23:55:35Z
dc.identifierMENDES, Fernanda Souza Nogueira Sardinha et al. Effect of Physical Exercise Training in Patients With Chagas Heart Disease (from the PEACH STUDY). American Journal of Cardiology, v. 125, n. 9, p. 1413-1420, 2020.
dc.identifier0002-9149
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/41251
dc.identifier10.1016/j.amjcard.2020.01.035
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8895666
dc.descriptionChagas heart disease (HD) is a chronic fibrosing myocarditis with high mortality. The PEACH study aimed to evaluate if exercise training can improve the functional capacity of Chagas HD patients with left ventricular dysfunction and/or heart failure. The PEACH study was a single center, parallel-group, clinical trial that randomized 30 clinical stable Chagas HD patients with left ventricular ejection fraction <45% or heart failure symptoms to either supervised exercise training 3 times/week for 6 months or a control group. Both groups had the same monthly pharmaceutical and nutritional counseling and usual care. Primary end point was functional capacity assessed by peak exercise oxygen consumption (peak VO2) obtained by cardiopulmonary exercise test. Secondary end points included other cardiopulmonary exercise test variables, cardiac function by echocardiography, body composition, muscle respiratory strength, and metabolic biomarkers. Peak VO2 increased among patients in exercise group from 17.60 ± 4.65 mlO2 kg-1 min-1 to 19.40 ± 5.51 mlO2 kg-1 min-1 while decreased in controls from 15.40 ± 6.30 mlO2 kg-1 min-1 to 12.96 ± 4.50 mlO2 kg-1 min-1, resulting in significant difference in change in peak VO2 between groups after 6 months (β = +4.6, p = 0.004). There were significant differences between groups in changes in anaerobic threshold (β = 3.7, p = 0.05), peak oxygen pulse (β = +2.7, p = 0.032) and maximum minute ventilation (β = +13.9, p < 0.0001) after 6 months of intervention. In conclusion, exercise training improved functional capacity of chronic Chagas HD patients with left ventricular dysfunction and/or heart failure.
dc.description2030-12-31
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectChagas heart disease
dc.subjectHeart failure
dc.subjectExercise training
dc.subjectCardiopulmonary exercise test
dc.titleEffect of Physical Exercise Training in Patients With Chagas Heart Disease (from the PEACH STUDY)
dc.typePreprint


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