Immune response triggered by Brucella abortus following infection or vaccination.

dc.creatorDorneles, Elaine Maria Seles
dc.creatorCarvalho, Andréa Teixeira de
dc.creatorAraújo, Márcio Sobreira Silva
dc.creatorSriranganathan, Nammalwar
dc.creatorLage, Andrey Pereira
dc.date2016-02-16T13:12:06Z
dc.date2016-02-16T13:12:06Z
dc.date2015
dc.date.accessioned2023-09-26T23:53:21Z
dc.date.available2023-09-26T23:53:21Z
dc.identifierDORNELES, Elaine Maria Seles et al. Immune response triggered by Brucella abortus following infection or vaccination. Vaccine, vol. 33, n. 31, p. 3659–3666, 2015
dc.identifier0264-410X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12730
dc.identifier10.1016/j.vaccine.2015.05.057
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8895292
dc.descriptionBrucella abortus live vaccines have been used successfully to control bovine brucellosis worldwide for decades. However, due to some limitations of these live vaccines, efforts are being made for the development of new safer and more effective vaccines that could also be used in other susceptible species. In this context, understanding the protective immune responses triggered by B. abortus is critical for the development of new vaccines. Such understandings will enhance our knowledge of the host/pathogen interactions and enable to develop methods to evaluate potential vaccines and innovative treatments for animals or humans. At present, almost all the knowledge regarding B. abortus specific immunological responses comes from studies in mice. Active participation of macrophages, dendritic cells, IFN-γ producing CD4+ T-cells and cytotoxic CD8+ T-cells are vital to overcome the infection. In this review, we discuss the characteristics of the immune responses triggered by vaccination versus infection by B. abortus, in different hosts
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectBovine brucellosis
dc.subjectBrucellosis vaccines
dc.subjectImmune response
dc.subjectRB51
dc.subjectS19
dc.titleImmune response triggered by Brucella abortus following infection or vaccination.
dc.typeArticle


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