Incidence of antiretroviral adverse drug reactions in pregnant women in two referral centers for HIV prevention of mother-to-child-transmission care and research in Rio de Janeiro, Brazil

dc.creatorOliveira, Marilia Santini
dc.creatorFriedman, Ruth Khalili
dc.creatorVeloso, Valdiléa G.
dc.creatorCunha, Cynthia Braga
dc.creatorPilotto, José Henrique
dc.creatorMarins, Luana Monteiro Spindola
dc.creatorJoão, Esaú Custódio
dc.creatorTorres, Thiago Silva
dc.creatorGrinsztejn, Beatriz
dc.date2015-04-16T17:17:24Z
dc.date2015-04-16T17:17:24Z
dc.date2014
dc.date.accessioned2023-09-26T23:53:18Z
dc.date.available2023-09-26T23:53:18Z
dc.identifierOLIVEIRA, Marilia Santini et al. Incidence of antiretroviral adverse drug reactions in pregnant women in two referral centers for HIV prevention of mother-to-child-transmission care and research in Rio de Janeiro, Brazil. Brazilian Journal of Infectious Diseases, v. 18, n. 4, p. 372-378, 2014.
dc.identifier1413-8670
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10033
dc.identifier10.1016/j.bjid.2013.11.008
dc.identifier1678-4391
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8895284
dc.descriptionMother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) infection remains an important cause of new HIV infections worldwide, especially in low and middle-resource limited countries. Safety data from studies involving pregnant women and prenatal antiretroviral (ARV) exposure are still needed once these studies are often small and with a limited duration to assess adverse drug reactions (ADR). The aim of this study was to estimate the incidence of ADR related to the use of antiretroviral therapy (ART) in pregnant women in two referral centers in Rio de Janeiro State. A prospective study was carried out from February 2005 to May 2006. Women were classified according to their ART status during pregnancy diagnosis: ARV-experienced (ARTexp) or ARV-naïve (ARTn). Two hundred fourteen HIV-infected pregnant women were included: 36 ARTexp and 178 ARTn. ARTexp women have not experienced ADR. Among ARTn, 20.2% presented ADR. Incidence rate of ADR was 70.8 per 1000 person-months and the most common ADRs observed were: gastrointestinal (belly or abdominal cramps, diarrhea, nausea and vomit) in 16.3%, cutaneous (pruritus and rash) in 6.2%, anemia (2.2%) and hepatitis (1.7%). The frequency of obstetrical complications, pre-term delivery, low birth weight and birth abnormalities was low in this population. ADRs ranged from mild to moderate intensity, none of them being potentially fatal. Only in a few cases it was necessary to discontinue ART. In conclusion, the high effectiveness of ARV for HIV prevention of MTCT (PMTCT) overcomes the risk of ADR.
dc.formatapplication/pdf
dc.languagepor
dc.publisherElsevier
dc.rightsopen access
dc.subjectHIV
dc.subjectAntiretroviral
dc.subjectPrevention of mother-to-child
dc.subjectTransmission
dc.subjectAdverse drug reaction
dc.subjectToxicity
dc.subjectHIV Infections/transmission
dc.subjectHIV/immunology
dc.subjectAnti-Retroviral Agents/immunology
dc.subjectToxicity
dc.subjectDrug-Related Side Effects and Adverse Reactions
dc.titleIncidence of antiretroviral adverse drug reactions in pregnant women in two referral centers for HIV prevention of mother-to-child-transmission care and research in Rio de Janeiro, Brazil
dc.typeArticle


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