Endocytic pathway in mouse cardiac cells

dc.creatorSoeiro, Maria de Nazaré C.
dc.creatorMota, Renata Alves
dc.creatorBatista, Denise da Gama Jaen
dc.creatorMeirelles, Maria de Nazareth Leal
dc.date2020-03-24T19:00:07Z
dc.date2020-03-24T19:00:07Z
dc.date2002
dc.date.accessioned2023-09-26T23:52:45Z
dc.date.available2023-09-26T23:52:45Z
dc.identifierSOEIRO, Maria Nazaré Correia et al. Endocytic pathway in mouse cardiac cells. Cell Structure and Function, v. 27, p. 469-478, 2002.
dc.identifier0386-7196
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/40494
dc.identifier10.1247/csf.27.469
dc.identifier1347-3700
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8895189
dc.descriptionPrimary cultures of heart muscle cells provide powerful tools for cardiac cell biological research that permits both physiological and biochemical approaches. In the present study we analyzed the endocytosis of cardiac cells and presented morphological characterization of the endocytic machinery using markers, which enabled us to follow the fluid-phase, receptor-mediated endocytosis and the internalization of large particles. Our results demonstrated the route of the internalized cargo to early endosomes followed or not by its discharge in the late compartments. We also confirmed the ability of cardiac muscle cells to ingest large particles such as the mannosylated ligand zymosan A, and even internalize whole eukaryotic cells such as the protozoan parasite Trypanosoma cruzi. Since endocytosis is involved in many important cellular functions, the present work contributes to the knowledge of possible additional roles played by cardiac muscle cells besides their well known ability to act as physically energetic cells in the body, constantly contracting without tiring.
dc.formatapplication/pdf
dc.languageeng
dc.publisherJapan Society of Cell Biology
dc.rightsopen access
dc.subjectCardiomiócitos
dc.subjectEndocitose
dc.subjectMicroscopia eletrônica
dc.subjectTrypanosoma cruzi
dc.subjectCardiomyocites
dc.subjectEndocytosis
dc.subjectElectron microscopy
dc.subjectTrypanosoma cruzi
dc.titleEndocytic pathway in mouse cardiac cells
dc.typeArticle


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