| dc.creator | Menezes, Isis Oliveira | |
| dc.creator | Scherf, Jackelyne Roberta | |
| dc.creator | Martins, Anita Oliveira Brito Pereira Bezerra | |
| dc.creator | Ramos, Andreza Guedes Barbosa | |
| dc.creator | Quintans, Jullyana de Souza Siqueira | |
| dc.creator | Coutinho, Henrique Douglas Melo | |
| dc.creator | Ribeiro Filho, Jaime | |
| dc.creator | Menezes, Irwin Rose Alencar de | |
| dc.date | 2021-11-03T14:28:17Z | |
| dc.date | 2021-11-03T14:28:17Z | |
| dc.date | 2021 | |
| dc.date.accessioned | 2023-09-26T23:52:21Z | |
| dc.date.available | 2023-09-26T23:52:21Z | |
| dc.identifier | MENEZES, Isis Oliveira et al. Biological properties of terpinolene evidenced by in silico, in vitro and in vivo tests: a systematic review. Phytomedicine, 2021. | |
| dc.identifier | https://www.arca.fiocruz.br/handle/icict/49641 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8895119 | |
| dc.description | Coordination for the Improvement of Higher Education Personnel - Brazil (CAPES),
Cearense Foundation to Support Scientific and Technological Development (FUNCAP) - finance code BPI, National Council for
Scientific and Technological Development (CNPq) – finance code 304291/2017-0, and Financier of Studies and Projects - Brasil
(FINEP). This article is a contribution of the National Institute of Science and Technology - Ethnobiology, Bioprospecting and
Nature Conservation/CNPq/FACEPE. | |
| dc.description | Background: Terpinolene, a monoterpene that is naturally found in a variety of herbs, is widely used as a flavoring agent in the
industry. Although it’s well established in the literature that terpinolene is an important component of plant extracts, the biological
properties and the potential therapeutic use of this compound remain poorly explored.
Purpose: This work aimed to answer the following guiding question: "What are the biological activities of terpinolene
demonstrated through in silico, in vitro, and in vivo assays?". and answered the guiding question. The analysis of these studies indicated that terpinolene presents a series of biological effects,
from which the antioxidant, larvicide, and insecticide activities stand out. Despite the evidence demonstrating that terpinolene has
the potential to be used in a broad pharmacological context, the mechanisms underlying its cellular and molecular effects remain to
be better elucidated. In addition, the in vivo efficacy and safety of the administration of this compound have been poorly evaluated
through either preclinical and clinical trials. Therefore, this study highlights the importance of characterizing the biological aspects
and mechanisms of action of this natural compound.
Conclusion: The data summarized in the present systematic review demonstrates the pharmacological potential of terpinolene.
Nevertheless, most studies included in this review provide a superficial characterization of terpinolene biological effects and
therefore, further research elucidating its mechanism of action and potential therapeutic benefits through preclinical and clinical
trials are required. Nevertheless, due to its wide range of different biological activities, terpinolene will certainly attract the interest
of scientific research, which could significantly contribute to the development of new products with both therapeutic and
environmental applications. and answered the guiding question. The analysis of these studies indicated that terpinolene presents a series of biological effects,
from which the antioxidant, larvicide, and insecticide activities stand out. Despite the evidence demonstrating that terpinolene has
the potential to be used in a broad pharmacological context, the mechanisms underlying its cellular and molecular effects remain to
be better elucidated. In addition, the in vivo efficacy and safety of the administration of this compound have been poorly evaluated
through either preclinical and clinical trials. Therefore, this study highlights the importance of characterizing the biological aspects
and mechanisms of action of this natural compound.
Conclusion: The data summarized in the present systematic review demonstrates the pharmacological potential of terpinolene.
Nevertheless, most studies included in this review provide a superficial characterization of terpinolene biological effects and
therefore, further research elucidating its mechanism of action and potential therapeutic benefits through preclinical and clinical
trials are required. Nevertheless, due to its wide range of different biological activities, terpinolene will certainly attract the interest
of scientific research, which could significantly contribute to the development of new products with both therapeutic and
environmental applications. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Elsevier | |
| dc.rights | open access | |
| dc.subject | Acetilcolinesterase | |
| dc.subject | Revisão sistemática | |
| dc.subject | Lactato desidrogenase | |
| dc.subject | Microscopia eletrônica de varredura | |
| dc.subject | Substâncias Reativas com Ácido Tiobarbitúrico | |
| dc.subject | Acetylcholinesterase | |
| dc.subject | Systematic Review | |
| dc.subject | Lactate Dehydrogenase | |
| dc.subject | Microscopy, Electron, Scanning | |
| dc.subject | Thiobarbituric Acid Reactive Substances | |
| dc.title | Biological properties of terpinolene evidenced by in silico, in vitro and in vivo tests: a systematic review | |
| dc.type | Preprint | |
