Plication of the free wall of the left ventricle in dogs with doxorubicin-induced cardiomyopathy

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorde Andrade, James N.B.M.
dc.creatorCamacho, Aparecido A.
dc.creatorSantos, Paulo S.P.
dc.creatorFantinatti, Alexandra P.
dc.creatorNunes, Newton
dc.creatorStopiglia, Angelo J.
dc.date2014-05-27T11:21:16Z
dc.date2016-10-25T18:20:28Z
dc.date2014-05-27T11:21:16Z
dc.date2016-10-25T18:20:28Z
dc.date2005-02-01
dc.date.accessioned2017-04-06T01:12:24Z
dc.date.available2017-04-06T01:12:24Z
dc.identifierAmerican Journal of Veterinary Research, v. 66, n. 2, p. 238-243, 2005.
dc.identifier0002-9645
dc.identifierhttp://hdl.handle.net/11449/68130
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68130
dc.identifier10.2460/ajvr.2005.66.238
dc.identifierWOS:000226922600008
dc.identifier2-s2.0-14844327777
dc.identifier0000-0002-8535-5569
dc.identifierhttp://dx.doi.org/10.2460/ajvr.2005.66.238
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889508
dc.descriptionObjective - To evaluate plication of the free wall of the left ventricle, which reduces the left ventricular area and volume, as a method to improve the left ventricular systolic function without cardiopulmonary bypass. Animals - 8 mixed-breed adult dogs. Procedure - Dilated cardiomyopathy (DCM) was induced in each dog by administration of doxorubicin (30 mg/m2, IV, q 21 d for 168 days). Two dogs died during induction of cardiomyopathy. Plication surgery was performed in 4 dogs. Two dogs did not ondergo to surgery (control group). Values for cardiac output (CO), 2-dimensional and M-mode echocardiography, arterial blood pressure, electrocardiography, blood cell counts, and serum biochemical analyses were recorded after induction of DCM (baseline) and 1, 2, 7, 15, 21, 30, 60, 90, 120, 150, and 180 days after plication surgery. Ambulatory ECG (Holter) recordings were conducted for 24 hours on the day of surgery. Results - 1 dog died after plication surgery. The remaining dogs undergoing ventricular plication had a significant improvement in CO, ejection fraction, and fractional shortening and reductions of left ventricular area and volume after surgery. Electrocardiographic and Holter recordings revealed premature ventricular complexes, which resolved without treatment during the first week after surgery. Clinical condition of the control dogs declined, and these 2 dogs died approximately 40 days after induction of cardiomyopathy. Conclusions and Clinical Relevance - Plication of the free wall of the left ventricle improved left ventricular systolic function in dogs with doxorubicin-induced cardiomyopathy. Additional studies are needed to evaluate its application in dogs with naturally developing DCM.
dc.languageeng
dc.relationAmerican Journal of Veterinary Research
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdoxorubicin
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectarterial pressure
dc.subjectblood analysis
dc.subjectblood cell count
dc.subjectblood vessel wall
dc.subjectcardiopulmonary bypass
dc.subjectcongestive cardiomyopathy
dc.subjectcontrolled study
dc.subjectdeath
dc.subjectdog disease
dc.subjectdrug induced disease
dc.subjectheart ejection fraction
dc.subjectheart left ventricle
dc.subjectheart left ventricle function
dc.subjectheart left ventricle volume
dc.subjectheart output
dc.subjectheart surgery
dc.subjectHolter monitoring
dc.subjectM mode echocardiography
dc.subjectnonhuman
dc.subjectsurgical technique
dc.subjecttreatment outcome
dc.subjecttwo dimensional echocardiography
dc.subjectAnimals
dc.subjectAntibiotics, Antineoplastic
dc.subjectCardiac Output
dc.subjectCardiomyopathy, Dilated
dc.subjectDisease Models, Animal
dc.subjectDog Diseases
dc.subjectDogs
dc.subjectDoxorubicin
dc.subjectEchocardiography
dc.subjectStroke Volume
dc.subjectSystole
dc.subjectVentricular Remodeling
dc.subjectAnimalia
dc.subjectCanis familiaris
dc.titlePlication of the free wall of the left ventricle in dogs with doxorubicin-induced cardiomyopathy
dc.typeOtro


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