Implantation failures: Success of assisted hatching with quarter-laser zona thinning

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPetersen, Cláudia G.
dc.creatorMauri, A. L.
dc.creatorBaruffi, R. L.
dc.creatorOliveira, J. B A
dc.creatorMassaro, F. C.
dc.creatorElder, K.
dc.creatorFranco, J. G.
dc.date2014-05-27T11:21:16Z
dc.date2016-10-25T18:20:27Z
dc.date2014-05-27T11:21:16Z
dc.date2016-10-25T18:20:27Z
dc.date2005-02-01
dc.date.accessioned2017-04-06T01:12:19Z
dc.date.available2017-04-06T01:12:19Z
dc.identifierReproductive BioMedicine Online, v. 10, n. 2, p. 224-229, 2005.
dc.identifier1472-6483
dc.identifierhttp://hdl.handle.net/11449/68121
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68121
dc.identifier10.1016/S1472-6483(10)60944-3
dc.identifierWOS:000226849500015
dc.identifier2-s2.0-13844291256
dc.identifierhttp://dx.doi.org/10.1016/S1472-6483(10)60944-3
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889500
dc.descriptionImplantation failure after IVF is one of the factors associated with a reduced chance of pregnancy for some patients. Assisted hatching methodologies are designed to facilitate the embryo's escape from the zona pellucida, and this strategy has been suggested as a means of improving pregnancy rates in patients with previous implantation failure. The aim of this prospective and randomized study was to evaluate the efficacy of quarter-laser zona thinning assisted hatching (qLZT-AH) in improving the implantation of embryos in patients with previous implantation failure. A total of 150 patients with a history of previous implantation failure were treated with intracytoplasmic sperm injection, and allocated into two groups: group 1, only one previous implantation failure, and group 2, repeated implantation failures. The patients in each group were randomized at the time of embryo transfer into a control group (no qLZT-AH) or experimental group where qLZT-AH was performed. For patients with repeated implantation failures, the implantation rate in those who received laser-thinned embryos was significantly higher (P=0.02) than in those whose embryos were not laser-thinned (10.9 and 2.6% respectively). However, this difference was not observed in patients who presented with only one previous implantation failure. The data demonstrate that qLZT-AH is an effective strategy for improving the implantation of embryos in patients with repeated implantation failures.
dc.languageeng
dc.relationReproductive BioMedicine Online
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectImplantation failure
dc.subjectQuarter-laser zona thinning and assisted hatching
dc.subjectnafarelin acetate
dc.subjectrecombinant follitropin
dc.subjectadult
dc.subjectclinical trial
dc.subjectcontrolled clinical trial
dc.subjectcontrolled study
dc.subjectdata analysis
dc.subjectembryo
dc.subjectembryo transfer
dc.subjectexperimental design
dc.subjectfemale
dc.subjecthuman
dc.subjectinfertility therapy
dc.subjectintracytoplasmic sperm injection
dc.subjectlaser
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectnidation
dc.subjectpregnancy rate
dc.subjectprospective study
dc.subjectquarter laser zona thinning assisted hatching
dc.subjectrandomized controlled trial
dc.subjectstatistical significance
dc.subjecttreatment failure
dc.subjecttreatment planning
dc.subjectzona pellucida
dc.subjectAdult
dc.subjectEmbryo Implantation
dc.subjectEmbryo Transfer
dc.subjectFemale
dc.subjectFertilization in Vitro
dc.subjectHumans
dc.subjectInfertility
dc.subjectLasers
dc.subjectPregnancy
dc.subjectPregnancy Outcome
dc.subjectProspective Studies
dc.subjectSperm Injections, Intracytoplasmic
dc.subjectZona Pellucida
dc.titleImplantation failures: Success of assisted hatching with quarter-laser zona thinning
dc.typeOtro


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