Systematic microvascular endothelial dysfunction and disease severity in COVID-19 patients: Evaluation by laser Doppler perfusion monitoring and cytokine/chemokine analysis

dc.creatorSabioni, Letícia
dc.creatorLorenzo, Andrea De
dc.creatorLamas, Cristiane
dc.creatorMuccillo, Fabiana
dc.creatorFaria Neto, Hugo Caire C.
dc.creatorEstato, Vanessa
dc.creatorTibiriça, Eduardo
dc.date2020-12-29T14:33:47Z
dc.date2020-12-29T14:33:47Z
dc.date2020
dc.date.accessioned2023-09-26T23:50:49Z
dc.date.available2023-09-26T23:50:49Z
dc.identifierSABIONI, Letícia et al. Systemic microvascular endothelial dysfunction and disease severity in COVID-19 patients: Evaluation by laser Doppler perfusion monitoring and cytokine/chemokine analysis. Microvascular Research, v. 134, 104119, p. 1-10, Dec. 2020.
dc.identifier0026-2862
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/45463
dc.identifier10.1016/j.mvr.2020.104119
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8894852
dc.descriptionCristiane Lamas. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento.
dc.descriptionDisponível on line em dezembro de 2020. Open Access pathways permitted by this journal's policy are listed below by article version. Click on a pathway for a more detailed view.Published Version [pathway b] - No Embargo Institutional Repository, Subject Repository, PMC, Research for Development Repository.
dc.descriptionSince January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
dc.descriptionBackground: Microvascular dysfunction, serum cytokines and chemokines may play important roles in pathophysiology of coronavirus disease 2019 (COVID-19), especially in severe cases. Methods: Patients with COVID-19 underwent non-invasive evaluation of systemic endothelium-dependent microvascular reactivity - using laser Doppler perfusion monitoring in the skin of the forearm - coupled to local thermal hyperemia. Maximal microvascular vasodilatation (44 °C thermal plateau phase) was used as endpoint. A multiplex biometric immunoassay was used to assess a panel of 48 serum cytokines and chemokines. Severe COVID-19 (S-COVID) was defined according to WHO criteria, while all other cases of COVID-19 were considered mild to moderate (M-COVID). A group of healthy individuals who tested negative for SARS-CoV-2 served as a control group and was also evaluated with LDPM. Results: Thirty-two patients with COVID-19 (25% S-COVID) and 14 controls were included. Basal microvascular flow was similar between M-COVID and controls (P = 0.69) but was higher in S-COVID than in controls (P = 0.005) and M-COVID patients (P = 0.01). The peak microvascular vasodilator response was markedly decreased in both patient groups (M-COVID, P = 0.001; S-COVID, P < 0.0001) compared to the healthy group. The percent increases in microvascular flow were markedly reduced in both patient groups (M-COVID, P < 0.0001; S-COVID, P < 0.0001) compared to controls. Patients with S-COVID had markedly higher concentrations of dissimilar proinflammatory cytokines and chemokines, compared to patients with M-COVID. Conclusions: In patients with COVID-19, especially with S-COVID, endothelium-dependent microvascular vasodilator responses are reduced, while serum cytokines and chemokines involved in the regulation of vascular function and inflammation are increased.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectCOVID-19
dc.subjectDisfunção endotelial microvascular sistêmica
dc.subjectPacientes
dc.subjectMonitoramento
dc.subjectPerfusão por laser Doppler
dc.subjectAnálise de citocinas / quimiocinas
dc.subjectCOVID-19
dc.subjectLaser Doppler perfusion monitoring
dc.subjectPatients
dc.subjectLaser Doppler perfusion monitoring
dc.subjectEndothelial dysfunction
dc.subjectProinflammatory cytokine
dc.titleSystematic microvascular endothelial dysfunction and disease severity in COVID-19 patients: Evaluation by laser Doppler perfusion monitoring and cytokine/chemokine analysis
dc.typeArticle


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