Effects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBrandini, Daniela Atili
dc.creatorSala, Miguel Angel
dc.creatorLopes, Ruberval Armando
dc.creatorSemprini, Marisa
dc.creatorContrera, Mary Garcia Duarte
dc.date2014-05-27T11:21:15Z
dc.date2016-10-25T18:20:22Z
dc.date2014-05-27T11:21:15Z
dc.date2016-10-25T18:20:22Z
dc.date2005-01-01
dc.date.accessioned2017-04-06T01:12:02Z
dc.date.available2017-04-06T01:12:02Z
dc.identifierBrazilian Dental Journal, v. 16, n. 1, p. 62-66, 2005.
dc.identifier0103-6440
dc.identifierhttp://hdl.handle.net/11449/68088
dc.identifierhttp://acervodigital.unesp.br/handle/11449/68088
dc.identifier10.1590/S0103-64402005000100011
dc.identifierS0103-64402005000100011
dc.identifier2-s2.0-28444469826.pdf
dc.identifier2-s2.0-28444469826
dc.identifierhttp://dx.doi.org/10.1590/S0103-64402005000100011
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889469
dc.descriptionThe purpose of this study was to investigate the effects of cigarette smoke on the development of the embryo mandible (Meckel's) cartilage in rat fetuses. When inhaled by female Wistar rats between the 9th and the 12th day of pregnancy, cigarette smoke (5 cigarettes a day) caused intrauterine growth retardation, providing smaller fetuses and placentas. In fetuses from the experimental group, the histopathologic examination revealed a poorly developed Meckel' s cartilage with smaller chondroblasts showing a scanty cytoplasm with spherical and paler central nuclei, as well as more abundant cartilage matrix. Morphometric analysis revealed that Meckel's cartilage lacunae were smaller in the fetuses from the experimental group, although not showing any remarkable alteration in shape. The results suggested that inhalation of cigarette smoke by pregnant rats during the organogenic period induced growth retardation and delayed cellular differentiation in rat fetal Meckel's cartilage.
dc.languageeng
dc.relationBrazilian Dental Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCigarette smoke
dc.subjectMeckel's cartilage
dc.subjectMorphometry
dc.subjectRat fetus
dc.subjectanimal
dc.subjectcartilage
dc.subjectfemale
dc.subjectfetus weight
dc.subjectindoor air pollution
dc.subjectintrauterine growth retardation
dc.subjectmandible
dc.subjectorganogenesis
dc.subjectpathology
dc.subjectplacenta
dc.subjectpregnancy
dc.subjectprenatal development
dc.subjectrat
dc.subjectthree dimensional imaging
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectCartilage
dc.subjectFemale
dc.subjectFetal Growth Retardation
dc.subjectFetal Weight
dc.subjectImaging, Three-Dimensional
dc.subjectMandible
dc.subjectOrganogenesis
dc.subjectPlacenta
dc.subjectPregnancy
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectTobacco Smoke Pollution
dc.titleEffects of cigarette smoke on the Meckel's cartilage of rat fetus : Morphologic, morphometric and stereologic study
dc.typeOtro


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