Alpha-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis

dc.creatorCouto, Fábio David
dc.creatorAlbuquerque, Alessandra B. Lima
dc.creatorAdorno, Elisângela Vitória
dc.creatorAbbehusen, L. de Freitas
dc.creatorOliveira, J. L. B. de
dc.creatorReis, Mitermayer Galvão dos
dc.creatorGonçalves, Marilda de Souza
dc.date2012-07-17T21:13:06Z
dc.date2012-07-17T21:13:06Z
dc.date2003
dc.date.accessioned2023-09-26T23:49:47Z
dc.date.available2023-09-26T23:49:47Z
dc.identifierCOUTO, Fábio David et al. Alpha-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis. Clinical and Laboratory Haematology, v. 25, n. 1, p. 29-34, Feb. 2003.
dc.identifier0141-9854
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/4176
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8894664
dc.descriptionAlpha-Thalassemia is a synthesis hemoglobinopathy with a worldwide distribution. alpha-thalassemia-23.7kb (alpha-Thal23.7kb) was investigated by PCR and standard hematologic analysis techniques in 106 pregnant women - 53 heterozygous for hemoglobin (Hb) A and C (AC) and 53 homozygous for the normal Hb A (AA) with similar ages and race ancestry. Eleven (21%) of AC women were alpha-Thal23.7kb heterozygous and 1 (2%) was homozygous, while 12 AA women (23%) were heterozygous. In the AA group, the MCV differed among those with normal alpha genes and those with alpha-Thal23.7kb (P = 0.031). Statistical analysis of AC group patients with normal alpha genes and alpha-Thal23.7kb carriers showed differences in MCV (P = 0.001); MCH (P = 0.003) and Hb C concentrations (P = 0.011). Analysis of AA and AC group patients with normal alpha genes showed differences in RBC (P = 0.033), Hb concentration (P = 0.003) and MCHC (P < 0.0001). There were no statistically significant differences for any hematologic parameters between AC and AA group patients with the alpha-Thal23.7kb genotype. The AC alpha-Thal23.7kb homozygous women had low hematologic parameters. Serum ferritin levels were normal among the groups studied. These results emphasize the importance of diagnosis and follow-up of patients with hemoglobinopathy carriers during pregnancy in order to administer adequate therapy and avoid further complications for mothers and newborns.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectHemoglobinopathies
dc.subjectHemoglobin C
dc.subjectPregnancy
dc.subjectThalassemia
dc.subjectHematologic parameters
dc.subjectDeleção de Sequência
dc.subjectTalassemia alfa/genética
dc.subjectEstudos de Casos e Controles
dc.subjectGrupos de Populações Continentais
dc.subjectFeminino
dc.subjectTestes Genéticos
dc.subjectTestes Hematológicos
dc.subjectHemoglobina A
dc.subjectHemoglobina C
dc.subjectHeterozigoto
dc.subjectHumanos
dc.subjectGravidez
dc.subjectTalassemia alfa/diagnóstico
dc.titleAlpha-Thalassemia 2, 3.7 kb deletion and hemoglobin AC heterozygosity in pregnancy: a molecular and hematological analysis
dc.typeArticle


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