Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil)

dc.creatorMartins, Liline Maria Soares
dc.creatorWanke, Bodo
dc.creatorLazéra, Márcia dos Santos
dc.creatorTrilles, Luciana
dc.creatorBarbosa, Gláucia Gonçalves
dc.creatorMacedo, Regina Célia Lima
dc.creatorCavalcanti, Maria do Amparo Salmito
dc.creatorEulálio, Kelsen Dantas
dc.creatorCastro, José Adail Fonseca
dc.creatorSilva, Adalberto Socorro
dc.creatorNascimento, Fernando Ferraz
dc.creatorGouveia, Viviane Alves
dc.creatorMonte, Semiramis Jamil Hadad
dc.date2019-11-18T13:37:58Z
dc.date2019-11-18T13:37:58Z
dc.date2011
dc.date.accessioned2023-09-26T23:49:40Z
dc.date.available2023-09-26T23:49:40Z
dc.identifierMARTINS, Liline Maria Soares et al. Genotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 106, n. 6, p. 725-730, Sept. 2011.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/37110
dc.identifier10.1590/S0074-02762011000600012
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8894645
dc.descriptionThroughout Brazil, Cryptococcus neoformans is the cause of cryptococcosis, whereas Cryptococcus gattii is endemic to the northern and northeastern states. In this study, the molecular types of 63 cryptococcal isolates recovered from the cerebrospinal fluid of meningitis patients diagnosed between 2008-2010 in Teresina, Piauí, Brazil, were analysed. Out of the 63 patients, 37 (58.7%) were human immunodeficiency virus (HIV)-positive and 26 (41.3%) were HIV-negative. URA5-restriction fragment length polymorphism analysis identified 37/63 (58.7%) isolates as the C. neoformans VNI genotype, predominantly in HIV-positive patients (32/37, 86.5%), and 24/63 (38.1%) as the C. gattii VGII genotype, mostly in HIV-negative patients (21/26, 80.8%). The occurrence of C. gattii VGII in six apparently healthy children and in seven adolescents/young adults in this region reaffirms the endemic occurrence of C. gattii VGII-induced primary cryptococcosis and early cryptococcal infection. Lethality occurred in 18/37 (48.6%) of the HIV-positive subjects and in 13/26 (50%) of the HIV-negative patients. Our results provide new information on the molecular epidemiology of C. neoformans and C. gattii in Brazilian endemic areas.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInstituto Oswaldo Cruz, Ministério da Saúde
dc.rightsopen access
dc.subjectCryptococcus gattii
dc.subjectCryptococcus neoformans
dc.subjectGenotypes
dc.subjectEndemic mycoses
dc.subjectChildren
dc.subjectImmunocompetent host
dc.titleGenotypes of Cryptococcus neoformans and Cryptococcus gattii as agents of endemic cryptococcosis in Teresina, Piauí (northeastern Brazil)
dc.typeArticle


Este ítem pertenece a la siguiente institución