Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals

dc.creatorGeiger, Stefan Michael
dc.creatorFujiwara, Ricardo Toshio
dc.creatorFreitas, Paula Albuquerque
dc.creatorMassara, Cristiano Lara
dc.creatorCarvalho, Omar dos Santos
dc.creatorOliveira, Rodrigo Corrêa
dc.creatorBethony, Jeffrey Michael
dc.date2014-11-04T12:58:39Z
dc.date2014-11-04T12:58:39Z
dc.date2011
dc.date.accessioned2023-09-26T23:49:23Z
dc.date.available2023-09-26T23:49:23Z
dc.identifierGEIGER, Stefan Michael et al. Excretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals. Journal of Biomolecular Structure & Dynamics, 2011: 512154,2011.
dc.identifier1538-0254
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8714
dc.identifier10.1155/2011/512154
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8894594
dc.descriptionFogarty Foundation, Fiocruz/CNPq
dc.descriptionWe compared the effects of larval and adult worm excretory-secretory (ES) products from hookworm on the proliferative responses and cytokine secretion in peripheral blood mononuclear cells (PBMCs) from hookworm patients and egg-negative, nonendemic controls. When compared with negative controls, mitogen-stimulated PBMC from hookworm-infected individuals showed a significantly reduced proliferative response when adult worm ES antigen was added to the cultures. Furthermore, in hookworm-infected individuals a significant downmodulation of inflammatory interleukin (IL)-6 and tumor necrosis factor (TNF)-α secretion resulted when PBMCs were stimulated with mitogen in combination with larval or adult worm ES. Both, interferon (IFN)-γ and IL-10 secretion were significantly lower in stimulated PBMC from infected individuals; however the IFN-γ/IL-10 ratio was much lower in hookworm-infected patients. Comparable effects, although at lower concentrations, were achieved when PBMCs from both groups were incubated with living hookworm third-stage larvae. We suggest that hookworm ES products downmodulate proliferative responses and inflammation during the chronic phase of the disease and facilitate early larval survival or adult worm persistence in the gut.
dc.formatapplication/pdf
dc.languageeng
dc.publisherAdenine Press
dc.rightsopen access
dc.subjectHookworm
dc.subjectcytokine secretion
dc.subjectNecator americanus
dc.titleExcretory-Secretory Products from Hookworm L3 and Adult Worms Suppress Proinflammatory Cytokines in Infected Individuals
dc.typeArticle


Este ítem pertenece a la siguiente institución