Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody

dc.creatorSilva, Maria Luiza
dc.creatorAzevedo, Ana Carolina Campi
dc.creatorBatista, Mauricio Azevedo
dc.creatorMartins, Marina Angela
dc.creatorAvelar, Renato Sathler
dc.creatorLemos, Denise da Silveira
dc.creatorCamacho, Luiz Antonio Bastos
dc.creatorMartins, Reinaldo de Menezes
dc.creatorMaia, Maria de Lourdes de Sousa
dc.creatorFarias, Roberto Henrique Guedes
dc.creatorFreire, Marcos da Silva
dc.creatorGaller, Ricardo
dc.creatorHomma, Akira
dc.creatorRibeiro, Jose Geraldo Leite
dc.creatorLemos, Jandira Aparecida Campos
dc.creatorMartins, Maria Auxiliadora
dc.creatorSantos, Silvana Maria Eloi
dc.creatorCarvalho, Andréa Teixeira
dc.creatorMartins Filho, Olindo Assis
dc.date2015-01-08T11:35:53Z
dc.date2015-01-08T11:35:53Z
dc.date2011
dc.date.accessioned2023-09-26T23:48:15Z
dc.date.available2023-09-26T23:48:15Z
dc.identifierSILVA, Maria Luiza et al. Cytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody. J Infect Dis, vol. 204, n. 6, p. 873-883, 2011.
dc.identifier0022-1899
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/9344
dc.identifier10.1093/infdis/jir439.
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8894388
dc.descriptionBackground. The live attenuated yellow fever (YF) vaccines have been available for decades and are considered highly effective and one of the safest vaccines worldwide. Methods. The impact of YF-17DD-antigens recall on cytokine profiles of YF-17DD-vaccinated children were characterized using short-term cultures of whole blood samples and single-cell flow cytometry. This study enrolled seroconverters and nonseroconverters after primovaccination (PV-PRNT1 and PV-PRNT2), seroconverters after revaccination (RV-PRNT1), and unvaccinated volunteers (UV-PRNT2). Results. The analysis demonstrated in the PV-PRNT1 group a balanced involvement of pro-inflammatory/ regulatory adaptive immunity with a prominent participation of innate immunity pro-inflammatory events (IL-121 and TNF-a1 NEU and MON). Using the PV-PRNT1 cytokine signature as a reference profile, PV-PRNT2 presented a striking lack of innate immunity proinflammatory response along with an increased adaptive regulatory profile (IL-41CD41 T cells and IL-101 and IL-51CD81 T cells). Conversely, the RV-PRNT1 shifted the overall cytokine signatures toward an innate immunity pro-inflammatory profile and restored the adaptive regulatory response. Conclusions. The data demonstrated that the overall cytokine signature was associated with the levels of PRNT antibodies with a balanced innate/adaptive immunity with proinflammatory/regulatory profile as the hallmark of PV-PRNTMEDIUM1, whereas a polarized regulatory response was observed in PV-PRNT2 and a prominent proinflammatory signature was the characteristic of PV-PRNTHIGH1.
dc.formatapplication/pdf
dc.languageeng
dc.publisherInfectious Diseases Society of America
dc.rightsopen access
dc.subjectAntibodies
dc.subjectViral/blood
dc.subjectCytokines/secretion
dc.subjectLeukocytes
dc.subjectMononuclear/immunology
dc.subjectYellow Fever Vaccine/administration & dosage
dc.titleCytokine Signatures of Innate and Adaptive Immunity in 17DD Yellow Fever Vaccinated Children and Its Association With the Level of Neutralizing Antibody
dc.typeArticle


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