The activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi

dc.creatorLopes, Marcela Silva
dc.creatorSales Júnior, Policarpo Ademar
dc.creatorLopes, Amanda Gervásio Ferreira
dc.creatorYoshida, Maria Irene
dc.creatorSilva, Thais Horta Alvares da
dc.creatorRomanha, Alvaro José
dc.creatorAlves, Ricardo José
dc.creatorOliveira, Renata Barbosa de
dc.date2014-11-13T15:27:00Z
dc.date2014-11-13T15:27:00Z
dc.date2011
dc.date.accessioned2023-09-26T23:47:57Z
dc.date.available2023-09-26T23:47:57Z
dc.identifierLOPES, Marcela Silva et al. The activity of a metronidazole analogue and its beta-cyclodextrin complex against Trypanosoma cruzi. Memorias do Instituto Oswaldo Cruz, 106(8): 1055-1067, 2011.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8829
dc.identifier10.1590/S0074-02762011000800027
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8894334
dc.descriptionIn this study we prepared an inclusion complex between an iodide analogue of metronidazole (MTZ-I) and cyclodextrin (CD) to develop a safer and more effective method of treating Trypanosoma cruzi infections. According to our results, MTZ-I and MTZ-I:β-CD were 10 times more active than MTZ, demonstrating that the presence of an iodine atom on the side chain increased the trypanocidal activity while maintaining its cytotoxicity. The selective index shows that MTZ-I was 10 times more active against T. cruzi than it was against mammalian cells. The modification of MTZ side chains provides a promising avenue for the development of new drugs.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz.
dc.rightsopen access
dc.subjectnitroaromatic
dc.subjectcyclodextrin
dc.subjectChagas disease
dc.subjectTrypanosoma cruzi
dc.titleThe activity of a metronidazole analogue and its β-cyclodextrin complex against Trypanosoma cruzi
dc.typeArticle


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