Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case

dc.creatorBottecchia, Marcelle
dc.creatorIkuta, Nilo
dc.creatorNiel, Christian
dc.creatorAraujo, Natalia M.
dc.creatorO, Kycia M. R.
dc.creatorGomes, Selma A.
dc.date2018-08-02T14:19:13Z
dc.date2018-08-02T14:19:13Z
dc.date2008
dc.date.accessioned2023-09-26T23:47:44Z
dc.date.available2023-09-26T23:47:44Z
dc.identifierBOTTECCHIA, Marcelle; et al. Lamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case. Journal of Gastroenterology and Hepatology, v. 23, p. 67–72, 2008.
dc.identifier0815-9319
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/27793
dc.identifier10.1111/j.1440-1746.2007.05238.x
dc.identifier1440-1746
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8894294
dc.descriptionResistance to lamivudine therapy of chronic hepatitis B virus (HBV) infection occurs by mutation in the YMDD motif of the reverse transcriptase (rt) domain (rtM204V/I) of the virus polymerase, and is usually accompanied by rtL180M mutation. Here we investigated virological factors associated with hepatic failure in a 58-year-old male, chronically HBV-infected patient who died after 33 months of lamivudine therapy.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley
dc.rightsrestricted access
dc.subjectVirus da Hepatite B
dc.subjectterapia com lamivudina
dc.subjectResistência a medicamentos
dc.subjectMutações
dc.subjectCasos fatais
dc.subjectPolimerase
dc.subjecthepatitis B virus
dc.subjectlamivudine therapy
dc.subjectDrug resistance
dc.subjectMutations
dc.subjectFatal case
dc.subjectpolymerase
dc.titleLamivudine resistance and other mutations in the polymerase and surface antigen genes of hepatitis B virus associated with a fatal hepatic failure case
dc.typeArticle


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