β-Carboline Glucoalkaloids from Psychotria cupularis and Evaluation of Their Antileishmanial Activity

dc.creatorBarreto, Ivan Martins
dc.creatorMoreira, Paulo Otávio Lourenço
dc.creatorMacedo, Guadalupe Edilma Licona de
dc.creatorMaia, Daniela Nabak Bueno
dc.creatorAlves, Tânia Maria de Almeida
dc.creatorDjalma Menezes de Oliveira
dc.creatorCota, Betania Barros
dc.date2022-06-24T13:33:39Z
dc.date2022-06-24T13:33:39Z
dc.date2021
dc.date.accessioned2023-09-26T23:47:38Z
dc.date.available2023-09-26T23:47:38Z
dc.identifierBarreto, Ivan Martins. et al. β-Carboline Glucoalkaloids from Psychotria cupularis and Evaluation of Their Antileishmanial Activity. Rev. Bras. Farmacogn., v. 31, p. 709–714, 2021. doi.org/10.1007/s43450-021-00197-8
dc.identifier1981-528X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/53465
dc.identifier10.1007/s43450-021-00197-8
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8894278
dc.descriptionPurification of the crude ethanol extracts from leaves and stems of Psychotria cupularis (Müll.Arg.) Standl., Rubiaceae, resulted in the isolation of the known monoterpene indole alkaloids ophiorine B and lyalosidic and strictosidinic acids. The antileishmanial activity values found for the isolated compounds highlighted ophiorine B as the most active against Leishmania (Viannia) braziliensis (IC50 100.50 μg/ml or 196.1 μM) and Leishmania (Leishmania) amazonensis (IC50 3.69 μg/ml or 7.2 μM) with a selectivity index of 108.6 to the human acute monocytic leukemia THP-1 cells. To the best of our knowledge, this is the first time that antileishmanial β-carboline glucoalkaloids were isolated from the studied material plant, contributing to the pharmacological potential of the genus.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsrestricted access
dc.subjectNeglected tropical disease
dc.subjectOphiorine alkaloids
dc.subjectSpectroscopic data
dc.subjectLeishmania
dc.subjectIntracellular amastigote assay
dc.subjectCytotoxic assay
dc.titleβ-Carboline Glucoalkaloids from Psychotria cupularis and Evaluation of Their Antileishmanial Activity
dc.typeArticle


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