Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia

dc.creatorDias, Rosane Borges
dc.creatorValverde, Ludmila de Faro
dc.creatorSales, Caroline Brandi Schlaepfer
dc.creatorGuimarães, Vanessa Sousa Nazaré
dc.creatorCabral, Márcia Grillo
dc.creatorXavier, Flávia Caló de Aquino
dc.creatorSantos, Jean Nunes dos
dc.creatorRamos, Eduardo Antônio Gonçalves
dc.creatorRocha, Clarissa Araújo Gurgel
dc.date2017-03-17T16:54:02Z
dc.date2017-03-17T16:54:02Z
dc.date2016
dc.date.accessioned2023-09-26T23:45:49Z
dc.date.available2023-09-26T23:45:49Z
dc.identifierDIAS, R. B. et al. Enhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia. Applied Immunohistochemistry & Molecular Morphology, v. 24, p. 595–602, 2016.
dc.identifier1541-2016
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18073
dc.identifier10.1097/PAI.0000000000000225
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893956
dc.descriptionNational Council for Scientific and Technological Development (CNPq, Brazil). Foundation to Support Research in the State of Bahia (FAPESB, Bahia, Brazil)
dc.descriptionThe aim of this study was to characterize the profile of the proteins involved in the Hedgehog signaling pathway to aid in the understanding of the pathogenesis of oral epithelial dysplasia (OED). The proteins SHH, PTCH1, HHIP, SUFU, GLI1, and cyclin D1 were evaluated by immunohistochemistry in 25 cases of OED, 4 of non-neoplasic oral mucosa, 8 of inflammatory fibrous hyperplasia and 5 of hyperkeratosis. SHH proteins were predominant in OED cases. Although PTCH1 protein was observed in all cases, this molecule was more highly expressed in OED. The inhibitor protein SUFU was present in OED and HHIP protein was overexpressed in OED. GLI1 proteins were predominantly found in the nuclei of epithelial cells in OED. Basal and suprabasal cells in the epithelial lining were positive for cyclin D1 only in OED. In conclusion, comparative analysis of the proteins involved in the Hedgehog pathway suggests that enhanced expression of these proteins can play an important role in the biological behavior of OED.
dc.formatapplication/pdf
dc.languageeng
dc.publisherLippincott, Williams & Wilkins
dc.rightsopen access
dc.subjectDisplasia epitelial oral
dc.subjectProteínas Hedgehog
dc.subjectLesão pré-maligna
dc.subjectOral epithelial dysplasia
dc.subjectHedgehog proteins
dc.subjectPremalignant lesion
dc.titleEnhanced Expression of Hedgehog Pathway Proteins in Oral Epithelial Dysplasia
dc.typeArticle


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