Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates

dc.creatorGama, Bianca Ervatti
dc.creatorOliveira, Natália Ketrin Almeida de
dc.creatorSouza, José Maria de
dc.creatorDaniel-Ribeiro, Cláudio Tadeu
dc.creatorCruz, Maria de Fátima Ferreira da
dc.date2018-08-23T12:14:11Z
dc.date2018-08-23T12:14:11Z
dc.date2009
dc.date.accessioned2023-09-26T23:44:42Z
dc.date.available2023-09-26T23:44:42Z
dc.identifierGAMA, Bianca Ervatti; et al. Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates. Mem Inst Oswaldo Cruz, v.104, n.7, p.1009-1011, Nov. 2009.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28309
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893756
dc.descriptionPlasmodium vivax control is now being hampered by drug resistance. Orthologous Plasmodium falciparum genes linked to chloroquine or sulfadoxine-pyrimethamine chemoresistance have been identified in P. vivax parasites, but few studies have been performed. The goal of the present work is to characterise pvmdr1 and pvdhfr genes in parasite isolates from a Brazilian endemic area where no molecular investigation had been previously conducted. The pvmdr1 analysis revealed the existence of single (85.7%) and double (14.3%) mutant haplotypes, while the pvdhfr examination showed the presence of double (57.2%) and triple (42.8%) mutant haplotypes. The implications of these findings are discussed.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz
dc.rightsopen access
dc.subjectPlasmodium vivax
dc.subjectMalária
dc.subjectquimiorresistência
dc.subjectPlasmodium vivax
dc.subjectmalaria
dc.subjectchemoresistance
dc.subjectpvmdr1
dc.subjectpvdhfr
dc.titleCharacterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates
dc.typeArticle


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