Killer cell immunoglobulin-like receptor (KIR) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil

dc.creatorSilva, D. S. Perce da
dc.creatorSilva, L. A.
dc.creatorLima Junior, J. C.
dc.creatorOliveira, J. Cardoso
dc.creatorAlves, M. RIbeiro
dc.creatorSantos, F.
dc.creatorPorto, L. C. M. S.
dc.creatorFerreira, J. Oliveira
dc.creatorBanic, D. M.
dc.date2015-10-27T14:47:24Z
dc.date2016-03-01T07:30:08Z
dc.date2015
dc.date.accessioned2023-09-26T23:44:35Z
dc.date.available2023-09-26T23:44:35Z
dc.identifierSILVA, D. S. Perce da; et al. Killer cell immunoglobulin-like receptor (KIR) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil. Tissue Antigens, v. 85, p.190–199, 2015.
dc.identifier0001-2815
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/12095
dc.identifier10.1111/tan.12523
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893740
dc.descriptionKiller cell immunoglobulin-like receptors (KIR) are expressed mainly in natural killer cells and specifically recognize human leukocyte antigen (HLA) class I molecules. The repertoire of KIR genes and KIR–HLA pairs is known to play a key role in the susceptibilities to and the outcomes of several diseases, including malaria. The aim of this study was to investigate the distribution of KIR genes, KIR genotypes and KIR–HLA pair combinations in a population naturally exposed to malaria from Brazilian Amazon. All 16 KIR genes investigated were present in the studied population. Overall, 46 KIR genotypes were defined. The two most common genotypes in the Porto Velho communities, genotypes 1 and 2, were present at similar frequencies as in the Americas. Principal component analysis based on the frequencies of the KIR genes placed the Porto Velho population closer to the Venezuela Mestizos, USA California hispanic and Brazil Paraná Mixed in terms of KIR gene frequencies. This analysis highlights the multi-ethnic profile of the Porto Velho population. Most of the individuals were found to have at least one inhibitory KIR–HLA pair. Seventy-five KIR–HLA pair combinations were identified. The KIR-2DL2/3_HLA-C1, KIR3DL1_HLA-Bw4 and KIR2DL1_HLA-C2 pairs were the most common. There was no association between KIR genes, KIR genotypes or KIR–HLA pair combinations and malaria susceptibility in the studied population. This is the first report on the distribution of KIR and known HLA ligands in the Porto Velho population. Taken together, these results should provide baseline information that will be relevant to population evolutionary history, malaria and other diseases studies in populations of the Brazilian Amazon.
dc.description2016-02-29
dc.formatapplication/pdf
dc.languageeng
dc.publisherJohn Wiley & Sons
dc.rightsopen access
dc.subjectHuman leukocyte antigen
dc.subjectBrazil
dc.subjectKiller cell immunoglobulin-like receptor (KIR)
dc.subjectMalaria
dc.subjectMalária
dc.subjectAntígenos HLA
dc.subjectBrasil
dc.subjectReceptores KIR
dc.titleKiller cell immunoglobulin-like receptor (KIR) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil
dc.typeArticle


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