Cost-effectiveness analysis of diagnostic tests for human visceral leishmaniasis in Brazil

dc.creatorAssis, Tália Santana Machado de
dc.creatorSilva, André Luis Azeredo da
dc.creatorWerneck, Guilherme Loureiro
dc.creatorRabello, Ana Lucia Teles
dc.date2017-04-03T17:58:04Z
dc.date2017-04-03T17:58:04Z
dc.date2016
dc.date.accessioned2023-09-26T23:44:24Z
dc.date.available2023-09-26T23:44:24Z
dc.identifierASSIS, Tália Santana Machado de et al. Cost-effectiveness analysis of diagnostic tests for human visceral leishmaniasis in Brazil. Trans R Soc Trop Med Hyg., v. 110, n. 8, p. 464-471, 2016
dc.identifier0035-9203
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/18253
dc.identifierhttps://doi.org/10.1093/trstmh/trw050
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893708
dc.descriptionBACKGROUND: The objective of study was to estimate the incremental cost-effectiveness ratio (ICER) of diagnostic options for visceral leishmaniasis (VL) in Brazil. METHODS: Six diagnostic tests were considered: IT LEISH, Kalazar Detect, DAT-LPC (DAT made in the Laboratório de Pesquisas Clínicas), IFAT, PCR and direct examination of bone marrow aspirate performed in either an ambulatory or a hospital setting. A database was built using the cost and effectiveness. The perspective of this study was the Brazilian public healthcare system and the results were expressed in costs per correctly diagnosed cases. RESULTS: In a favorable hypothetical scenario, DAT-LPC presented the lowest cost (US$4.92) and highest effectiveness (99%). Paired analyses showed that IT LEISH was dominant compared to IFAT, microscopy and Kalazar Detect and that Kalazar Detect was dominant over IFAT and microscopy. PCR was dominant over the bone marrow aspirate in the hospital and showed an ICER of 57.76 compared with aspirate in an ambulatory setting. CONCLUSIONS: These results highlight the need for the revision of algorithm for VL diagnostic in Brazil. Replacements of IFAT with DAT-LPC, Kalazar Detect with IT LEISH and bone marrow aspirate performed in a hospital setting with PCR are cost-effective public health measures.
dc.description2039-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherOxford University Press
dc.rightsrestricted access
dc.subjectLeishmaniose visceral
dc.subjectBrazil
dc.subjectCost-effectiveness
dc.subjectDiagnostic tests
dc.subjectVisceral leishmaniasis
dc.titleCost-effectiveness analysis of diagnostic tests for human visceral leishmaniasis in Brazil
dc.typeArticle


Este ítem pertenece a la siguiente institución