Molecular characterization and epidemiological aspects of non-polioenteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005-2017)

dc.creatorSousa Jr., Ivanildo P.
dc.creatorOliveira, Maria de Lourdes Aguiar
dc.creatorBurlandy, Fernanda M.
dc.creatorMachado, Raiana S.
dc.creatorOliveira, Silas S.
dc.creatorTavares, Fernando N.
dc.creatorGomes Neto, Francisco
dc.creatorCosta, Eliane V. da
dc.creatorSilva, Edson E. da
dc.date2020-12-03T13:56:44Z
dc.date2020-12-03T13:56:44Z
dc.date2020
dc.date.accessioned2023-09-26T23:44:04Z
dc.date.available2023-09-26T23:44:04Z
dc.identifierSOUSA JR., Ivanildo P. et al. Molecular characterization and epidemiological aspects of non-polio enteroviruses isolated from acute flaccid paralysis in Brasil: a historical series (2005-2017). Emerging Microbes & Infections, v. 9, p. 2536-2546, Dec. 2020.
dc.identifier2222-1751
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44713
dc.identifier10.1080/22221751.2020.1850181
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893647
dc.descriptionDue to the advanced stage of polio eradication, the possible role of non-polio enteroviruses (NPEVs) associated to acute flaccid paralysis (AFP) cases has been highlighted. In this study, we described epidemiological aspects of NPEVs infections associated to AFP and explore the viral genetic diversity, information still scarce in Brazil. From 2005 to 2017, 6707 stool samples were collected in the scope of the Brazilian Poliomyelitis Surveillance Program. NPEVs were isolated in 359 samples (5.3%) and 341 (94.9%) were genotyped. About 46 different NPEV types were identified with the following detection pattern EV-B > EV-A > EV-C. The major EV-types were CVA2, CV4, EV-A71, CVB3, CVB5, E6, E7, E11, CVA13 and EV-C99, which corresponds to 51.6% of the total. Uncommon types, such as CVA12, EV-90 and CVA11, were also identified. Different E6 genogroups were observed, prevailing the GenIII, despite periods of co-circulation, and replacement of genogroups along time. CVA2 sequences were classified as genotype C and data suggested its dispersion in South-American countries. CVA13 viruses belonged to cluster B and Venezuelan viruses composed a new putative cluster. This study provides extensive information on enterovirus diversity associated with AFP, reinforcing the need of tailoring current surveillance strategies to timely monitor emergence/re-emergence of NPEVs.
dc.formatapplication/pdf
dc.languageeng
dc.publisherTaylor & Francis
dc.rightsopen access
dc.subjectEnterovírus não-poliomielite
dc.subjectParalisia flácido aguda
dc.subjectEnterovirus
dc.subjectEpidemiologia molecular
dc.subjectVigilância da poliomielite
dc.subjectNon-polio enterovirus
dc.subjectAcute flaccid paralysis
dc.subjectEnterovirus
dc.subjectMolecular epidemiology
dc.subjectPoliomyelitis surveillance
dc.titleMolecular characterization and epidemiological aspects of non-polioenteroviruses isolated from acute flaccid paralysis in Brazil: a historical series (2005-2017)
dc.typeArticle


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