Helminths and Cancers From the Evolutionary Perspective

dc.creatorScholte, Larissa Lopes Silva
dc.creatorXavier, Marcelo Antonio Pascoal
dc.creatorNahum, Laila Alves
dc.date2018-09-17T13:57:12Z
dc.date2018-09-17T13:57:12Z
dc.date2018
dc.date.accessioned2023-09-26T23:43:57Z
dc.date.available2023-09-26T23:43:57Z
dc.identifierSCHOLTE, Larissa Lopes Silva; XAVIER, Marcelo Antonio Pascoal; NAHUM, Laila Alves. Helminths and Cancers From the Evolutionary Perspective. Front Med (Lausanne), v. 5, p. 90, 2018.
dc.identifier2296-858X
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28831
dc.identifier10.3389/fmed.2018.00090
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893629
dc.descriptionHelminths include free-living and parasitic Platyhelminthes and Nematoda which infect millions of people worldwide. Some Platyhelminthes species of blood flukes (Schistosoma haematobium, Schistosoma japonicum, and Schistosoma mansoni) and liver flukes (Clonorchis sinensis and Opisthorchis viverrini) are known to be involved in human cancers. Other helminths are likely to be carcinogenic. Our main goals are to summarize the current knowledge of human cancers caused by Platyhelminthes, point out some helminth and human biomarkers identified so far, and highlight the potential contributions of phylogenetics and molecular evolution to cancer research. Human cancers caused by helminth infection include cholangiocarcinoma, colorectal hepatocellular carcinoma, squamous cell carcinoma, and urinary bladder cancer. Chronic inflammation is proposed as a common pathway for cancer initiation and development. Furthermore, different bacteria present in gastric, colorectal, and urogenital microbiomes might be responsible for enlarging inflammatory and fibrotic responses in cancers. Studies have suggested that different biomarkers are involved in helminth infection and human cancer development; although, the detailed mechanisms remain under debate. Different helminth proteins have been studied by different approaches. However, their evolutionary relationships remain unsolved. Here, we illustrate the strengths of homology identification and function prediction of uncharacterized proteins from genome sequencing projects based on an evolutionary framework. Together, these approaches may help identifying new biomarkers for disease diagnostics and intervention measures. This work has potential applications in the field of phylomedicine (evolutionary medicine) and may contribute to parasite and cancer research.
dc.description2020-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media S.A
dc.rightsopen access
dc.subjectparasita
dc.subjectmicrobioma
dc.subjectcancer
dc.subjectbiomarcadores
dc.subjectfilogenia
dc.subjectevolução molecular
dc.subjectevolução da medicina
dc.subjectbioinformatica
dc.subjectparasite
dc.subjectmicrobiome
dc.subjectcancer
dc.subjectbiomarkers
dc.subjectphylogeny
dc.subjectmolecular evolution
dc.subjectevolutionary medicine
dc.subjectbioinformatics
dc.titleHelminths and Cancers From the Evolutionary Perspective
dc.typeArticle


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