Lipoic acid and ascorbic acid affect plasma free amino acids selectively in the teleost fish pacu (Piaractus mesopotamicus)

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorTerjesen, Bendik F.
dc.creatorPark, Kwan
dc.creatorTesser, Marcelo B.
dc.creatorPortella, Maria C.
dc.creatorZhang, Yongfang
dc.creatorDabrowski, Konrad
dc.date2014-05-27T11:21:11Z
dc.date2016-10-25T18:20:01Z
dc.date2014-05-27T11:21:11Z
dc.date2016-10-25T18:20:01Z
dc.date2004-11-01
dc.date.accessioned2017-04-06T01:10:47Z
dc.date.available2017-04-06T01:10:47Z
dc.identifierJournal of Nutrition, v. 134, n. 11, p. 2930-2934, 2004.
dc.identifier0022-3166
dc.identifierhttp://hdl.handle.net/11449/67938
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67938
dc.identifier2-s2.0-7944229614
dc.identifierhttp://jn.nutrition.org/content/134/11/2930.long
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889325
dc.descriptionMost studies on the antioxidants, lipoic acid (LA) and ascorbic acid (AA), focused on species that, unlike teleost fish, are not scurvy-prone, and are able to synthesize AA. The antioxidant properties of LA may make it useful in aquaculture nutrition, but several effects must first be investigated, and we address here plasma free amino acids (FAA). In mammals, LA and AA in high doses were claimed to alter plasma FAA profile; to our knowledge, however, no data are available in fish. We therefore studied the effects of dietary LA and AA on plasma FAA in the South American teleost fish pacu, which is being used increasingly in aquaculture. LA treatment decreased concentrations of 18 of 23 individual FAA; specifically, dispensable and total FAA were significantly affected. Ornithine was elevated (+26%) in LA-treated fish and significantly decreased ratios of plasma [Arg]/[Orn] and other individual [FAA]/[Orn] were observed. LA and AA both affected sulfur FAA concentrations. Plasma cystine levels were significantly increased in the LA-supplemented groups. AA had little effect on most amino acids, and no interaction with LA was detected. AA supplementation did, however, significantly lower taurine (-42%) and cystathionine (-31%) levels in plasma. No effect on the branched chain:aromatic amino acid ratios was observed. The data indicate that at the dietary level studied, LA and AA independently affect selected plasma FAA in pacu, and suggest that any use of LA in particular as a dietary supplement should take into account an altered plasma FAA profile.
dc.languageeng
dc.relationJournal of Nutrition
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntioxidant
dc.subjectAscorbic acid
dc.subjectFree amino acids
dc.subjectLipoic acid
dc.subjectTeleost
dc.subjectamino acid
dc.subjectantioxidant
dc.subjectarginine
dc.subjectascorbic acid
dc.subjectcystathionine
dc.subjectcystine
dc.subjectornithine
dc.subjectsulfur amino acid
dc.subjecttaurine
dc.subjectthioctic acid
dc.subjectamino acid blood level
dc.subjectamino acid metabolism
dc.subjectamino acid synthesis
dc.subjectanalytic method
dc.subjectanimal experiment
dc.subjectantioxidant activity
dc.subjectaquaculture
dc.subjectblood sampling
dc.subjectcontrolled study
dc.subjectdiet supplementation
dc.subjectdietary intake
dc.subjectfood composition
dc.subjectnitrogen metabolism
dc.subjectnonhuman
dc.subjectnutritional support
dc.subjectPiaractus mesopotamicus
dc.subjectteleost
dc.subjectAmino Acids
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectAscorbic Acid
dc.subjectCystathionine
dc.subjectDiet
dc.subjectFishes
dc.subjectTaurine
dc.subjectThioctic Acid
dc.subjectAnimalia
dc.subjectMammalia
dc.subjectPiaractus
dc.subjectteleost fish
dc.subjectTeleostei
dc.titleLipoic acid and ascorbic acid affect plasma free amino acids selectively in the teleost fish pacu (Piaractus mesopotamicus)
dc.typeOtro


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