Synergistic action of olive oil supplementation and dietary restriction on serum lipids and cardiac antioxidant defences

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorFaine, Luciane A.
dc.creatorDiniz, Yeda S.
dc.creatorGalhardi, Cristiano M.
dc.creatorRodrigues, Hosana G.
dc.creatorBurneiko, Regina C.
dc.creatorSantana, Lea S.
dc.creatorCicogna, Antonio Carlos
dc.creatorNovelli, Ethel L.B.
dc.date2014-05-27T11:21:10Z
dc.date2016-10-25T18:20:00Z
dc.date2014-05-27T11:21:10Z
dc.date2016-10-25T18:20:00Z
dc.date2004-11-01
dc.date.accessioned2017-04-06T01:10:43Z
dc.date.available2017-04-06T01:10:43Z
dc.identifierCanadian Journal of Physiology and Pharmacology, v. 82, n. 11, p. 969-975, 2004.
dc.identifier0008-4212
dc.identifierhttp://hdl.handle.net/11449/67920
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67920
dc.identifier10.1139/y04-092
dc.identifierWOS:000226483900005
dc.identifier2-s2.0-13544255565
dc.identifierhttp://dx.doi.org/10.1139/y04-092
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889318
dc.descriptionCaloric intake is higher than recommended in many populations. Therefore, enhancing olive oil intake alone may not be the most effective way to prevent cardiovascular diseases. The purpose of the present study was to analyse the association of olive oil and dietary restriction on lipid profile and myocardial antioxidant defences. Male Wistar rats (180-200 g, n = 6) were divided into 4 groups: control ad libitum diet (C), 50% restricted diet (DR), fed ad libitum and supplemented with olive oil (3 mL/(kg-day)) (OO), and 50% restricted diet and supplemented with olive oil (DROO). After 30 days of treatments, OO, DR, and DROO groups had increased total cholesterol and high-density lipoprotein cholesterol concentrations. DR and DROO animals showed decreased low-density lipoprotein cholesterol. DROO had the lowest low-density lipoprotein cholesterol concentration. Total lipids and triacylglycerols were raised by dietary restriction and diminished by olive oil. OO rats had higher myocardial Superoxide dismutase and lower catalase and glutathione peroxidase activities than C rats. DR and DROO showed enhanced cardiac Superoxide dismutase, catalase, and glutathione peroxidase activities from the control. Olive oil supplementation alone improved the lipid profile but was more effective when coupled with dietary restriction. There was a synergistic beneficial action of dietary restriction and olive oil on serum lipids and myocardial antioxidant defences.
dc.languageeng
dc.relationCanadian Journal of Physiology and Pharmacology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntioxidant enzymes
dc.subjectCardiac tissue
dc.subjectDietary restriction
dc.subjectLipid profile
dc.subjectOlive oil
dc.subjectantioxidant
dc.subjectcatalase
dc.subjectcholesterol
dc.subjectglutathione peroxidase
dc.subjecthigh density lipoprotein cholesterol
dc.subjectlipid
dc.subjectlow density lipoprotein cholesterol
dc.subjectolive oil
dc.subjectsuperoxide dismutase
dc.subjecttriacylglycerol
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectantioxidant activity
dc.subjectcaloric intake
dc.subjectcontrolled study
dc.subjectdiet restriction
dc.subjectdiet supplementation
dc.subjectenzyme activity
dc.subjectfat intake
dc.subjectglutathione metabolism
dc.subjectheart left ventricle
dc.subjectheart muscle metabolism
dc.subjectmale
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectAnimals
dc.subjectAntioxidants
dc.subjectCaloric Restriction
dc.subjectCholesterol
dc.subjectDietary Supplements
dc.subjectMale
dc.subjectMyocardium
dc.subjectPlant Oils
dc.subjectRats
dc.subjectRats, Wistar
dc.titleSynergistic action of olive oil supplementation and dietary restriction on serum lipids and cardiac antioxidant defences
dc.typeOtro


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