The role of cigarette smoking and liver enzymes polymorphisms in anti-tuberculosis drug-induced hepatotoxicity in brazilian patients

dc.creatorValle, Camila Zaverucha do
dc.creatorMonteiro, Sérgio Pereira
dc.creatorEl-Jaick, Kênia Balbi
dc.creatorRosadas, Leonardo Azevedo da Silva
dc.creatorCosta, Marli Jane Martins
dc.creatorQuintana, Marcel de Souza Borges
dc.creatorCastro, Liane de
dc.date2015-06-17T17:27:19Z
dc.date2015-06-17T17:27:19Z
dc.date2014
dc.date.accessioned2023-09-26T23:40:54Z
dc.date.available2023-09-26T23:40:54Z
dc.identifierVALLE, Camila Zaverucha do et al. The role of cigarette smoking and liver enzymes polymorphisms in anti-tuberculosis drug-induced hepatotoxicity in brazilian patients. Tuberculosis, v.94, n.3, p.299–305, 2014.
dc.identifier1472-9792
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10902
dc.identifier10.1016/j.tube.2014.03.006
dc.identifier1873-281X
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8893115
dc.descriptionPrograma Estratégico de Apoio à Pesquisa em Saúde, Fundação Oswaldo Cruz, FAPERJ
dc.descriptionTuberculosis (TB) is still a major health concern and side-effects related to the treatment, especially druginduced hepatotoxicity (DIH), should be better investigated. In the present study, a possible association between anti-TB DIH and cigarette smoking, N-acetyltransferase 2 (NAT2), Cytochrome P450 2E1 (CYP2E1) and Cytochrome P450 3A4 (CYP3A4) genotypes was studied in 131 TB Brazilian patients. The NAT2 and CYP3A4 genetic polymorphisms were determined using a polymerase chain reaction (PCR) direct sequencing approach and genetic polymorphisms of CYP2E1 gene were determined by restriction fragment length polymorphism (RFLP). The risk of anti-TB DIH was lower in rapid/intermediate acetylators when compared to slowacetylators (OR: 0.34, CI 95: 0.16e0.71; p < 0.01). A decreased risk of developing anti-TB DIH was also observed in active smokers when compared to non-smokers (OR: 0.28, 95 CI: 0.11e0.64; p < 0.01). Significant association between CYP3A4 genotypes and hepatotoxicity was not observed, as well as between CYP2E1 genotype and hepatotoxicity, whose frequency of patients with wild homozygous was more prevalent. The anti-TB drugs interactions with smoking on hepatotoxicity, as well as the NAT2 phenotype, may require to adjust therapeutic regimen dosages or alarm in case of adverse event developments.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsrestricted access
dc.subjectAnti-tuberculosis drug
dc.subjectHepatotoxicity
dc.subjectLiver enzymes
dc.subjectCigarette smoking
dc.subjectTuberculose
dc.subjectReação em Cadeia da Polimerase
dc.subjectPolimorfismo de Fragmento de Restrição
dc.subjectBrasil
dc.titleThe role of cigarette smoking and liver enzymes polymorphisms in anti-tuberculosis drug-induced hepatotoxicity in brazilian patients
dc.typeArticle


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