Correlation between susceptibility of primary HIV-1 isolates to autologous and heterologous neutralizing antibodies

dc.creatorBongertz, Vera
dc.creatorCosta, Catia I.
dc.creatorVeloso, Valdiléa G.
dc.creatorJoão Filho, Esaú C.
dc.creatorGalvão-Castro, Bernardo
dc.creatorMorgado, Mariza G.
dc.creatorHospital Evandro Chagas AIDS Clinical Research Group
dc.date2019-02-11T17:32:48Z
dc.date2019-02-11T17:32:48Z
dc.date1997
dc.date.accessioned2023-09-26T23:39:05Z
dc.date.available2023-09-26T23:39:05Z
dc.identifierBONGERTZ, Vera et al. Correlation between susceptibility of primary HIV-1 isolates to autologous and heterologous neutralizing antibodies. AIDS, v. 11, n. 8 p. 969-975, 1997.
dc.identifier0269-9370
dc.identifier9223730
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/31547
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8892793
dc.descriptionHospital Evandro Chagas AIDS Clinical Research Group: S. Cavalcante; M.C.G. Galhardo; M.R.C. Guimarães; B. Grinsztejn and V.C. Rolla.
dc.descriptionOBJECTIVE: To study the susceptibility of primary HIV-1 isolates towards autologous and heterologous neutralizing antibodies (NAb). DESIGN: Blood was collected and primary HIV-1 isolated from individuals residing in Rio de Janeiro, Brazil, in all phases of disease. METHODS: Primary HIV-1 isolates were incubated with autologous or heterologous plasma and neutralization of infection of freshly pre-stimulated normal human peripheral blood mononuclear cells was assayed in parallel to median infectious dose determinations in the absence of antibodies. Levels of HIV-1 p24 antigen were used for evaluation of viral neutralization. RESULTS: Autologous neutralization (75%) was observed for 13 (52%) out of 25 of the primary HIV-1 isolates, and 15 (71%) out of 21 isolates were susceptible to 75% heterologous neutralization by at least one-half of the heterologous plasma tested. Primary HIV-1 isolates susceptible to autologous NAb showed a higher susceptibility towards neutralization by heterologous NAb than isolates that could not be neutralized by the autologous plasma (P = 0.049). The susceptibility of the primary HIV-1 isolates towards neutralization by heterologous NAb was significantly higher for isolates derived from men (P = 0.001), and for isolates obtained from individuals infected through homo-/bisexual risk behaviour in comparison with those infected through heterosexual HIV-1 transmission (P = 0.03). CONCLUSIONS: Susceptibility of primary HIV-1 isolates to autologous and heterologous neutralization was significantly correlated, indicating that escape mutants may become resistant not only to autologous but also to heterologous NAb.
dc.description2050-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherRapid Science Publishers | Lippincott-Raven Publishers
dc.rightsrestricted access
dc.subjectPrimary HIV-1 isolates
dc.subjectAutologous neutralization
dc.subjectHeterologous neutralization
dc.titleCorrelation between susceptibility of primary HIV-1 isolates to autologous and heterologous neutralizing antibodies
dc.typeArticle


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