Natural variation of the cardiac transcriptome in humans

dc.creatorDomitrovic, Tatiana
dc.creatorMoreira, Mariana H.
dc.creatorCarneiro, Rodolfo L.
dc.creatorRibeiro-Alves, Marcelo
dc.creatorPalhano, Fernando L.
dc.date2021-12-09T22:05:31Z
dc.date2021-12-09T22:05:31Z
dc.date2021
dc.date.accessioned2023-09-26T23:38:47Z
dc.date.available2023-09-26T23:38:47Z
dc.identifierDOMITROVIC, Tatiana et al. Natural variation of the cardiac transcriptome in humans. RNA biology, v. 18, n. 10, p. 1374-138, 2021
dc.identifier1547-6286
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/50270
dc.identifier10.1080/15476286.2020.1857508
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8892740
dc.descriptionWe investigated the gene-expression variation among humans by analysing previously published mRNA-seq and ribosome footprint profiling of heart left-ventricles from healthy donors. We ranked the genes according to their coefficient of variation values and found that the top 5% most variable genes had special features compared to the rest of the genome, such as lower mRNA levels and shorter half-lives coupled to increased translation efficiency. We observed that these genes are mostly involved with immune response and have a pleiotropic effect on disease phenotypes, indicating that asymptomatic conditions contribute to the gene expression diversity of healthy individuals.
dc.formatapplication/pdf
dc.languageeng
dc.publisherTaylor & Francis
dc.rightsrestricted access
dc.subjectGene expression profiling
dc.subjectGenetic variation
dc.subjectHeart ventricles
dc.subjectHuman heart
dc.subjectRibosome profiling
dc.subjectTranslatome
dc.titleNatural variation of the cardiac transcriptome in humans
dc.typeArticle


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