Histomorphometric analysis of homogenous demineralized dentin matrix as osteopromotive material in rabbit mandibles

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorPinheiro Carvalho, Valéria Abrantes
dc.creatorDe Oliveira Tosello, Darcy
dc.creatorDe Castillo Salgado, Miguel Angel
dc.creatorFernandes Gomes, Mônica
dc.date2014-05-27T11:21:09Z
dc.date2016-10-25T18:19:53Z
dc.date2014-05-27T11:21:09Z
dc.date2016-10-25T18:19:53Z
dc.date2004-09-01
dc.date.accessioned2017-04-06T01:10:18Z
dc.date.available2017-04-06T01:10:18Z
dc.identifierInternational Journal of Oral and Maxillofacial Implants, v. 19, n. 5, p. 679-686, 2004.
dc.identifier0882-2786
dc.identifierhttp://hdl.handle.net/11449/67869
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67869
dc.identifierWOS:000224451600006
dc.identifier2-s2.0-7244245437
dc.identifierhttp://www.quintpub.com/journals/omi/abstract.php?iss2_id=134&article_id=1511
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889270
dc.descriptionPurpose: The aim of this work was to evaluate the effectiveness of homogenous demineralized dentin matrix (HDDM) slices in surgical bone defects created in the mandibles of rabbits and occluded with a polytetrafluoroethylene (PTFE) membrane in the promotion of bone growth. Materials and Methods: Surgical bone defects were created in 36 adult rabbits and divided into 4 groups: bone defect (control), bone defect with PTFE membrane, bone defect with HDDM, and bone defect with both HDDM and a PTFE membrane (HDDM + PTFE). The rabbits were sacrificed after 30, 60, and 90 days, and the bone defects were examined histologically and by histomorphometric analysis (analysis of variance and the Tukey test). Results: The volume of newly formed bone matrix was significantly greater in the HDDM and HDDM + PTFE groups than in the control and PTFE groups. The discrete inflammatory reaction found in the HDDM and HDDM + PTFE groups did not prevent the osteopromotive activity of the dentin matrix. Discussion: HDDM slices were biocompatible and were resorbed during the bone remodeling process. They stimulated the newly formed bone until 30 days after implantation. Conclusion: Bone repair was accelerated in the bone defects treated with HDDM in comparison to the control group.
dc.languageeng
dc.relationInternational Journal of Oral and Maxillofacial Implants
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectBone repair
dc.subjectGuided tissue regeneration
dc.subjectHomogenous demineralized dentin matrix
dc.subjectOsteopromotion
dc.subjectTissue engineering
dc.subjectanesthetic agent
dc.subjectantibiotic agent
dc.subjectdiclofenac
dc.subjectketamine
dc.subjectpentabiotic
dc.subjectpentabiotico
dc.subjectpolitef
dc.subjectrompum
dc.subjectunclassified drug
dc.subjectanalysis of variance
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectbone demineralization
dc.subjectbone growth
dc.subjectbone matrix
dc.subjectbone remodeling
dc.subjectcontrolled study
dc.subjectdentin
dc.subjectevaluation
dc.subjectexamination
dc.subjecthistology
dc.subjectinflammation
dc.subjectjaw malformation
dc.subjectmandible
dc.subjectmembrane
dc.subjectmorphometrics
dc.subjectnonhuman
dc.subjectosteolysis
dc.subjectrabbit
dc.subjectstimulation
dc.subjecttooth implantation
dc.subjecttooth occlusion
dc.subjectAnalysis of Variance
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectBone Matrix
dc.subjectBone Remodeling
dc.subjectBone Substitutes
dc.subjectDental Materials
dc.subjectDentin
dc.subjectGuided Tissue Regeneration
dc.subjectHaversian System
dc.subjectMandibular Diseases
dc.subjectMembranes, Artificial
dc.subjectOsteogenesis
dc.subjectPolytetrafluoroethylene
dc.subjectRabbits
dc.subjectTime Factors
dc.titleHistomorphometric analysis of homogenous demineralized dentin matrix as osteopromotive material in rabbit mandibles
dc.typeOtro


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