Phylogenetic and molecular analysis of HTLV-1 isolates from a medium sized town in northern of Brazil: tracing a common origin of the virus from the most endemic city in the country

dc.creatorMagalhães, Themístocles Soares de
dc.creatorMiranda, Aline Cristina Andrade Mota
dc.creatorAlcantara, Luiz Carlos Júnior
dc.creatorGallazzi, Viviana Nilla Olavarria
dc.creatorCastro Filho, Bernardo Galvão
dc.creatorGrassi, Maria Fernanda Rios
dc.date2014-07-29T19:47:13Z
dc.date2014-07-29T19:47:13Z
dc.date2008
dc.date.accessioned2023-09-26T23:36:39Z
dc.date.available2023-09-26T23:36:39Z
dc.identifierPhylogenetic and molecular analysis of HTLV-1 isolates from a medium sized town in northern of Brazil: tracing a common origin of the virus from the most endemic city in the country. Journal of Medical Virology, v. 80, n. 11, p. 2040-2045, 2008.
dc.identifier1096-9071
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/8097
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8892373
dc.descriptionSalvador-Bahia has the highest prevalence of HTLV-1 infection in Brazil; about 2% of the population is infected. In this city, the prevalence of HTLV in pregnant women is 1%. There is no data of the HTLV-1 prevalence in others cities of the Bahia’s Recoˆ ncavo, where the population has similar social and demography characteristics to those from Salvador. Our aim was to evaluate the seroprevalence of HTLV in pregnant women in Cruz das Almas-Bahia, a medium-sized city from the Bahia’s Recoˆ ncavo. All individuals were tested for HTLV (ELISA) and the positive samples were confirmed by Western Blot. Phylogenetic analyses of the total LTR region were performed in all positive samples. We tested 408 samples (45.4% of the estimate pregnant women population) between June 1st and October 31, 2005. The prevalence of HTLV-1 infection was 0.98%. In addition, all isolated virus were grouped in the subtype HTLV-1a, in the Latin American group. Our results suggest that the introduction of HTLV- 1 occurred after the slave trade into Salvador. In addition, HTLV-1-infection should be screened during the pregnancy in women originating from HTLV-1 endemic areas.
dc.formatapplication/pdf
dc.languageeng
dc.publisherWiley-Liss, INC
dc.rightsrestricted access
dc.subjectHTLV-1
dc.subjectPregnant women
dc.subjectPrevalence
dc.subjectMolecular epidemiology
dc.subjectDoenças Endêmicas
dc.subjectInfecções por HTLV-I/epidemiologia
dc.subjectInfecções por HTLV-I/virologia
dc.subjectVírus 1 Linfotrópico T Humano/classificação
dc.subjectVírus 1 Linfotrópico T Humano/isolamento & purificação
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectBrasil/epidemiologia
dc.subjectFeminino
dc.subjectVírus 1 Linfotrópico T Humano/genética
dc.subjectHumanos
dc.subjectEpidemiologia Molecular
dc.subjectDados de Sequência Molecular
dc.subjectFilogenia
dc.subjectGravidez
dc.subjectGestantes
dc.subjectAnálise de Sequência de DNA
dc.subjectHomologia de Sequência
dc.subjectEstudos Soroepidemiológicos
dc.titlePhylogenetic and molecular analysis of HTLV-1 isolates from a medium sized town in northern of Brazil: tracing a common origin of the virus from the most endemic city in the country
dc.typeArticle


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