NS1 Antigenemia and Viraemia Load: Potential Markers of Progression to Dengue Fatal Outcome?

dc.creatorNunes, Priscila Conrado Guerra
dc.creatorNogueira, Rita Maria Ribeiro
dc.creatorHeringer, Manoela
dc.creatorCarneiro, Thaís Chouin
dc.creatorRodrigues, Cintia Damasceno dos Santos
dc.creatorFilippis, Ana Maria Bispo de
dc.creatorLima, Monique da Rocha Queiroz
dc.creatorSantos, Flávia Barreto dos
dc.date2018-09-18T15:53:05Z
dc.date2018-09-18T15:53:05Z
dc.date2018
dc.date.accessioned2023-09-26T23:36:17Z
dc.date.available2023-09-26T23:36:17Z
dc.identifierNUNES, Priscila Conrado Guerra; et al. NS1 Antigenemia and Viraemia Load: Potential Markers of Progression to Dengue Fatal Outcome?. Viruses, v.10, n.326, 11p, June 2018.
dc.identifier1999-4915
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/28866
dc.identifier10.3390/v10060326
dc.identifier1999-4915
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8892310
dc.descriptionDengue is a worldwide problem characterized by a multifactorial pathogenesis. Considering the viral components, it is known that high viremia or high levels of the secreted nonstructural protein 1 (NS1) may be associated with a more severe disease. We aimed to characterize the NS1 antigenemia and viremia in dengue fatal and non-fatal cases, as potential markers of progression to a fatal outcome. NS1 antigenemia and viremia were determined in Brazilian dengue fatal cases (n = 40) and non-fatal cases (n = 40), representative of the four dengue virus (DENV) serotypes. Overall, the fatal cases presented higher NS1 levels and viremia. Moreover, the fatal cases from secondary infections showed significantly higher NS1 levels than the non-fatal ones. Here, irrespective of the disease outcome, DENV-1 cases presented higher NS1 levels than the other serotypes. However, DENV-2 and DENV-4 fatal cases had higher NS1 antigenemia than the non-fatal cases with the same serotype. The viremia in the fatal cases was higher than in the non-fatal ones, with DENV-3 and DENV-4 presenting higher viral loads. Viral components, such as NS1 and viral RNA, may be factors influencing the disease outcome. However, the host immune status, comorbidities, and access to adequate medical support cannot be ruled out as interfering in the disease outcome.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsopen access
dc.subjectDengue
dc.subjectCasos fatais
dc.subjectcarga de viremia
dc.subjectProteínas não Estruturais Virais
dc.subjectDengue
dc.subjectNS1 antigenemia
dc.subjectviraemia load
dc.subjectFatal cases
dc.titleNS1 Antigenemia and Viraemia Load: Potential Markers of Progression to Dengue Fatal Outcome?
dc.typeArticle


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