Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice

dc.creatorGonzaga, Beatriz Matheus Souza
dc.creatorHorita, Samuel Iwao Maia
dc.creatorBeghini, Daniela Gois
dc.creatorGomes, Fabiana
dc.creatorNisimura, Líndice Mitie
dc.creatorSantos, Isabele Barbieri dos
dc.creatorEstato, Vanessa
dc.creatorAraújo‑Jorge, Tania Cremonini de
dc.creatorGarzoni, Luciana Ribeiro
dc.date2023-01-15T13:14:09Z
dc.date2023-01-15T13:14:09Z
dc.date2022
dc.date.accessioned2023-09-26T23:36:05Z
dc.date.available2023-09-26T23:36:05Z
dc.identifierGONZAGA, Beatriz Matheus Souza et al. Effect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice. Scientific Reports, v. 12, 21048, p. 1 - 11, 2022.
dc.identifier2045-2322
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/56468
dc.identifier10.1038/s41598-022-25056-x
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8892273
dc.descriptionCentral nervous system alterations was described in Chagas disease in both human and experimental models, leading to meningoencephalitis, stroke and cognitive impairment. Recently, our group demonstrated that acute infection by Trypanossoma cruzi leads to cerebral microvasculophaty in mice with endothelial dysfunction, capillary rarefaction, increased rolling and leukocyte adhesion. Only benznidazole and nifurtimox are available for clinical treatment, they have an efficiency of 80% in the acute phase and less than 20% in chronic phase. However, the effect of these drugs on brain microcirculation has not yet been evaluated. We hypothesized that early treatment with benznidazole could protect brain microcirculation during acute experimental Chagas disease. Swiss Webster mice were inoculated with 104 trypomastigotes forms of T. cruzi, and after 24 h they were treated with 50 or 100 mg/kg/day of benznidazole for 14 consecutive days. In untreated infected mice, we observed cerebral microvascular rarefaction, increase in leukocyte rolling and adhesion, reduced cerebral blood flow, and increased CD3+ and F4-80+ cells in brain tissue. Early treatment with benznidazole at 100 mg/kg/day and 50 mg/kg/day prevented the occurrence of the alterations mentioned. Here, we show that BZ is able to protect the microcirculation and reduced brain inflammation in acute experimental Chagas disease.
dc.formatapplication/pdf
dc.languageeng
dc.publisherNature Portfolio
dc.rightsopen access
dc.subjectEfeito do benznidazol
dc.subjectMicrocirculação cerebral
dc.subjectDurante a Infecção por Trypanosoma cruzi
dc.subjectCamundongos
dc.subjectEffect of benznidazole
dc.subjectCerebral microcirculation
dc.subjectInfection in mice
dc.subjectDuring Acute Trypanosoma cruzi
dc.titleEffect of benznidazole on cerebral microcirculation during acute Trypanosoma cruzi infection in mice
dc.typeArticle


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