Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)

dc.creatorSouza, Márcia Maria de
dc.creatorSouza Junior, Miguel Tolentino de
dc.creatorAssis, Bárbara Cristina Alves de
dc.creatorGonzalez, Ana Cristina de Oliveira
dc.creatorSilva, Tânia Maria Correia
dc.creatorAndrade, Zilton de Araújo
dc.date2016-08-05T17:28:46Z
dc.date2016-08-05T17:28:46Z
dc.date2006
dc.date.accessioned2023-09-26T23:35:42Z
dc.date.available2023-09-26T23:35:42Z
dc.identifierSOUZA, Márcia Maria de et al. Pathogenesis of septal fibrosis of the liver. (An experimental study with a new model.). Pathology – Research and Practice, v. 202, p. 883–889, 2006.
dc.identifier0344-0338
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/15199
dc.identifier10.1016/j.prp.2006.07.004
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8892207
dc.descriptionSeptal fibrosis is an important, frequent, and non-specific type of fibrosis associated with chronic liver diseases, but its pathogenesis is still poorly understood. An interesting model of septal fibrosis occurs in rats infected with the nematode Capillaria hepatica. This model was used to investigate the pathogenesis, site of origin, structure, and cell-types of septal fibrosis. Forty young adult Wistar rats were inoculated with 800 embryonated eggs of C. hepatica. Daily liver samples were obtained from the 20th to the 39th day after inoculation to cover the critical period when septal fibrosis usually starts. Routine histology, electron microscopy, immunohistochemistry, and indirect immunofluorescence were applied to the study of liver sections. Septal blood vessels were demonstrated by India ink perfusion of the portal vein system. Prominent angiogenesis was observed to precede collagen deposition. Besides angiogenesis and mesenchymal-cell mobilization, septal fibrosis was seen to originate from portal spaces and to course through acinar zone I in between sinusoids, inducing no alterations in them, with no evident participation of stellate hepatic cells. Septal fibrosis appeared as an adaptative type of response of the liver to chronic injury, which resulted in a new structure that is normal to other species and creates accessory vessels that drain portal blood into hepatic sinusoids.
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier
dc.rightsopen access
dc.subjectHepatic fibrosis
dc.subjectSeptal fibrosis
dc.subjectCapillaria hepatica
dc.subjectAngiogenesis
dc.titlePathogenesis of septal fibrosis of the liver. (An experimental study with a new model.)
dc.typeArticle


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