Autophagy in protists

dc.creatorDuszenko, Michael
dc.creatorGinger, Michael L.
dc.creatorBrennand, Ana
dc.creatorGualdrón-López, Melisa
dc.creatorColombo, Maria-Isabel
dc.creatorCoombs, Graham H.
dc.creatorCoppens, Isabelle
dc.creatorJayabalasingham, Bamini
dc.creatorLangsley, Gordon
dc.creatorCastro, Solange Lisboa de
dc.creatorMenna-Barreto, Rubem
dc.creatorMottram, Jeremy C.
dc.creatorNavarro, Miguel
dc.creatorRigden, Daniel J.
dc.creatorRomano, Patricia S.
dc.creatorStoka, Veronika
dc.date2016-09-27T17:22:47Z
dc.date2016-09-27T17:22:47Z
dc.date2011
dc.date.accessioned2023-09-26T23:35:18Z
dc.date.available2023-09-26T23:35:18Z
dc.identifierDUSZENKO, Michael; et al. Autophagy in protists. Autophagy, v.7, n.2, p.127-158, Feb. 2011.
dc.identifier1554-8627
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/15975
dc.identifier1554-8635
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8892134
dc.descriptionAutophagy is the degradative process by which eukaryotic cells digest their own components using acid hydrolases within the lysosome. Originally thought to function almost exclusively in providing starving cells with nutrients taken from their own cellular constituents, autophagy is in fact involved in numerous cellular events including differentiation, turnover of macromolecules and organelles and defense against parasitic invaders. During the past 10–20 years, molecular components of the autophagic machinery have been discovered, revealing a complex interactome of proteins and lipids, which, in a concerted way, induce membrane formation to engulf cellular material and target it for lysosomal degradation. Here, our emphasis is autophagy in protists. We discuss experimental and genomic data indicating that the canonical autophagy machinery characterized in animals and fungi appeared prior to the radiation of major eukaryotic lineages. Moreover, we describe how comparative bioinformatics revealed that this canonical machinery has been subject to moderation, outright loss or elaboration on multiple occasions in protist lineages, most probably as a consequence of diverse lifestyle adaptations. We also review experimental studies illustrating how several pathogenic protists either utilize autophagy mechanisms or manipulate host-cell autophagy in order to establish or maintain infection within a host. The essentiality of autophagy for the pathogenicity of many parasites, and the unique features of some of the autophagy-related proteins involved, suggest possible new targets for drug discovery. Further studies of the molecular details of autophagy in protists will undoubtedly enhance our understanding of the diversity and complexity of this cellular phenomenon and the opportunities it offers as a drug target.
dc.description2030-01-01
dc.formatapplication/pdf
dc.languageeng
dc.publisherTaylor & Francis
dc.rightsrestricted access
dc.subjectAutofagia
dc.subjectUbiquitinação
dc.subjectTrypanosomatina
dc.subjectApicomplexa
dc.subjectDescoberta de drogas
dc.subjectDiferenciação do ciclo de vida
dc.subjectautophagy
dc.subjectubiquitination
dc.subjectpexophagy
dc.subjectevolution
dc.subjectfree-living protist
dc.subjectparasitic protist
dc.subjectlife-cycle differentiation
dc.subjectTrypanosomatidae
dc.subjectApicomplexa
dc.subjectdrug discovery
dc.titleAutophagy in protists
dc.typeArticle


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