Acellular dermal tissue study: an ultrastructural evaluation of human and porcine derived tissues in a rat model

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorHoyama, E.
dc.creatorSchellini, Silvana Artioli
dc.creatorGregório, E. A.
dc.creatorRossa, R.
dc.date2014-05-27T11:21:06Z
dc.date2016-10-25T18:19:43Z
dc.date2014-05-27T11:21:06Z
dc.date2016-10-25T18:19:43Z
dc.date2004-07-01
dc.date.accessioned2017-04-06T01:09:44Z
dc.date.available2017-04-06T01:09:44Z
dc.identifierJournal of Submicroscopic Cytology and Pathology, v. 36, n. 3-4, p. 305-308, 2004.
dc.identifier1122-9497
dc.identifierhttp://hdl.handle.net/11449/67796
dc.identifierhttp://acervodigital.unesp.br/handle/11449/67796
dc.identifier2-s2.0-17444412218
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15906605
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/889207
dc.descriptionThe purpose of this study was to evaluate the host response of a human and a porcine derived acellular dermal tissue (ADT) implanted in the subcutaneous tissue of a rat model. Two subcutaneous pockets were surgically created along the dorsal midline of 25 rats (5 rats/group). The human ADT was placed superiorly and the porcine ADT, inferiorly. The animals were sacrificed at 07, 15, 30, 60 and 180 postoperative days (PO) and the ADTs and surrounding soft tissues were assessed for ultrastructural evaluation by transmission electron microscopy. The ultrastructural findings were similar in both materials. Normal collagen and elastic fibers bundles were observed during all experimental moments, as well as macrophages presenting cytoplasmic enlargements digesting cellular portions after 15 PO. From 30 until 180 PO, vacuolar structures filled with an amorphous, electron-transparent substance, were present inside and outside the fibroblasts. Both human and porcine ADT showed similar pattern of ultrastructural response when implanted in the subcutaneous tissue of rats. The porcine ADT appears as a good alternative to be used as a biomaterial.
dc.languageeng
dc.relationJournal of Submicroscopic Cytology and Pathology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcellular dermal tissue
dc.subjectBiomaterial
dc.subjectExperimental study
dc.subjectUltrastructure
dc.subjectcollagen
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectcontrolled study
dc.subjectcytoplasm
dc.subjectdermis
dc.subjectelastic fiber
dc.subjectfibroblast
dc.subjectmacrophage
dc.subjectmale
dc.subjectnonhuman
dc.subjectrat
dc.subjectsoft tissue
dc.subjectsubcutaneous tissue
dc.subjecttransmission electron microscopy
dc.subjectultrastructure
dc.subjectAnimals
dc.subjectCollagen
dc.subjectEosinophils
dc.subjectFibroblasts
dc.subjectHumans
dc.subjectMacrophages
dc.subjectMale
dc.subjectMicroscopy, Electron, Transmission
dc.subjectModels, Animal
dc.subjectRats
dc.subjectSkin
dc.subjectSkin Transplantation
dc.subjectSubcutaneous Tissue
dc.subjectSwine
dc.subjectVacuoles
dc.titleAcellular dermal tissue study: an ultrastructural evaluation of human and porcine derived tissues in a rat model
dc.typeOtro


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