Candida glabrata produces a melanin-like pigment that protects against stress conditions encountered during parasitism

dc.creatorAlmeida-Paes, Rodrigo
dc.creatorFigueiredo-Carvalho, Maria H. G.
dc.creatorSilva, Leandro B. R. da
dc.creatorGerfen, Gary
dc.creatorAraújo, Glauber R. de S.
dc.creatorFrases, Susana
dc.creatorZancopé-Oliveira, Rosely M.
dc.creatorNosanchuk, Joshua D.
dc.date2021-08-04T19:55:25Z
dc.date2021-08-04T19:55:25Z
dc.date2021
dc.date.accessioned2023-09-26T23:34:25Z
dc.date.available2023-09-26T23:34:25Z
dc.identifierALMEIDA-PAES, Rodrigo et al. Candida glabrata produces a melanin-like pigment that protects against stress conditions encountered during parasitism. Future microbiology, v. 16, p. 509-520, 2021
dc.identifier1746-0913
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/48491
dc.identifier10.2217/fmb-2020-0228
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8892026
dc.descriptionAim: Melanin has been linked to pathogenesis in several fungi. They often produce melanin-like pigments in the presence of L-dihydroxyphenylalanine (L-DOPA), but this is poorly studied in Candida glabrata. Methods & materials: C. glabrata was grown in minimal medium with or without L-DOPA supplementation and submitted to a chemical treatment with denaturant and hot acid. Results: C. glabrata turned black when grown in the presence of L-DOPA, whereas cells grown without L-DOPA supplementation remained white. Biophysical properties demonstrated that the pigment was melanin. Melanized C. glabrata cells were effectively protected from azoles and amphotericin B, incubation at 42°C and macrophage killing. Conclusion: In the presence of L-DOPA, C. glabrata produces melanin, increases antifungal resistance and enhances host survival.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFuture Medicine
dc.rightsrestricted access
dc.subjectCandida glabrata
dc.subjectL-DOPA
dc.subjectMelanin
dc.subjectSurvival
dc.subjectVirulence
dc.titleCandida glabrata produces a melanin-like pigment that protects against stress conditions encountered during parasitism
dc.typeArticle


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