Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon

dc.creatorLizcano, Omaira Vera
dc.creatorResende, Sarah Stela
dc.creatorMelo, Yonne Francis Chehuan
dc.creatorLacerda, Marcus Vinicius Guimarães de
dc.creatorBrito, Cristiana Ferreira Alves de
dc.creatorZalis, Mariano Gustavo
dc.date2015-04-28T16:54:53Z
dc.date2015-04-28T16:54:53Z
dc.date2014
dc.date.accessioned2023-09-26T23:33:43Z
dc.date.available2023-09-26T23:33:43Z
dc.identifierLIZCANO, Omaira Vera et al. Genetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon. Mem Inst Oswaldo Cruz, Rio de Janeiro, Vol. 109, n. 7, p. 948-951, 2014
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/10133
dc.identifier10.1590/0074-0276140241
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891899
dc.descriptionCAPES, FAPEAM, CNPq
dc.descriptionThe molecular basis of Plasmodium vivax chloroquine (CQ) resistance is still unknown. Elucidating the mo¬lecular background of parasites that are sensitive or resistant to CQ will help to identify and monitor the spread of resistance. By genotyping a panel of molecular markers, we demonstrate a similar genetic variability between in vitro CQ-resistant and sensitive phenotypes of P. vivax parasites. However, our studies identified two loci (MS8 and MSP1-B10) that could be used to discriminate between both CQ-susceptible phenotypes among P. vivax iso¬lates in vitro. These preliminary data suggest that microsatellites may be used to identify and to monitor the spread of P. vivax-resistance around the world.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz
dc.rightsopen access
dc.subjectPlasmodium vivax
dc.subjectchloroquine
dc.subjectresistance
dc.titleGenetic diversity of chloroquine-resistant Plasmodium vivax parasites from the western Brazilian Amazon
dc.typeArticle


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