Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients

dc.creatorGama, Wellington Mota
dc.creatorOliveira, Lucas Barbosa
dc.creatorChaves, Yury Oliveira
dc.creatorRibeiro, Flavio
dc.creatorAlmeida, Taynná Vernalha Rocha
dc.creatorBaptista, Barbara Jose Antunes
dc.creatorSantana, Monique Freire
dc.creatorFerreira, Luis Carlos
dc.creatorLacerda, Marcus Vinicius Guimaraes
dc.creatorNogueira, Paulo Afonso
dc.date2020-10-06T18:02:36Z
dc.date2020-10-06T18:02:36Z
dc.date2020
dc.date.accessioned2023-09-26T23:33:32Z
dc.date.available2023-09-26T23:33:32Z
dc.identifierGAMA, Wellington Mota et al. Increased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 115: e200082, 5p, 2020.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/43833
dc.identifier10.1590/0074-02760200082
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891865
dc.descriptionRespiratory failure (RF) is the main cause of hospital admission in HIV/AIDS patients. This study assessed comorbidities and laboratory parameters in HIV/AIDS inpatients with RF (N = 58) in relation to those without RF (N = 36). Tuberculosis showed a huge relative risk and platelet counts were slightly higher in HIV/AIDS inpatients with RF. A flow cytometry assay for reactive oxygen species (ROS) showed lower levels in platelets of these patients in relation to the healthy subjects. However, when stimulated with adrenaline, ROS levels increased in platelets and platelet-derived microparticles of HIV/AIDS inpatients, which may increase the risk of RF during HIV and tuberculosis (HIV-TB) coinfection.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectHIV/AIDS
dc.subjectPlaquetas e micropartículas derivadas de plaquetas
dc.subjectEspécies reativas de oxigênio
dc.subjectInsuficiência respiratória
dc.subjectHIV/AIDS
dc.subjectRespiratory failure
dc.subjectReactive oxygen species
dc.subjectPlatelets and platelet-derived microparticles
dc.titleIncreased levels of reactive oxygen species in platelets and platelet-derived microparticles and the risk of respiratory failure in HIV/AIDS patients
dc.typeArticle


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