Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin.

dc.creatorLima, Flávia Oliveira de
dc.creatorNonato, Fabiana Regina
dc.creatorCouto, Ricardo David
dc.creatorBarbosa Filho, José Maria
dc.creatorNunes, Xirley Pereira
dc.creatorSantos, Ricardo Ribeiro dos
dc.creatorSoares, Milena Botelho Pereira
dc.creatorVillarreal, Cristiane Flora
dc.date2012-11-23T18:03:25Z
dc.date2012-11-23T18:03:25Z
dc.date2011
dc.date.accessioned2023-09-26T23:33:32Z
dc.date.available2023-09-26T23:33:32Z
dc.identifierLIMA, F.O. de et al. Mechanisms involved in the antinociceptive effects of 7-hydroxycoumarin. Journal of Natural Products, v. 74, n. 4, p. 596-602, apr. 2011.
dc.identifier1520-6025
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/5864
dc.identifier10.1021/np100621c
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891864
dc.description7-Hydroxycoumarin (umbelliferone, 1), the main metabolite of coumarin, has been reported to produce potent antinociceptive effects in animal models of pain. However, the biochemical events involved in antinociception mediated by 1 are currently not well understood. In the present study, the mechanisms by which 1 exerts its pharmacological actions were investigated. Acute pretreatment of mice with 1 produced a long-lasting antinociceptive effect against complete Freund's adjuvant (CFA)-induced hyperalgesia. The subchronic administration of 1 inhibited CFA-induced hyperalgesia and paw edema, while it did not cause any apparent toxicity. Another set of experiments showed that 1 inhibited carrageenan-induced mechanical hyperalgesia, but not mechanical hyperalgesia induced by prostaglandin E(2) (PGE(2)), suggesting that it acts upstream of PGE(2.) Treatment with 1 was able to prevent the plantar tissue neutrophil influx induced by local inflammatory stimuli. In addition, 1 exhibited inhibitory effects on the release of hyperalgesic cytokines (TNF-α and IL-1ß) and the production of PGE(2), a directly acting hyperalgesic mediator. The present results suggest that the antinociceptive effect of 1 is correlated with the inhibition of neutrophil migration, cytokine release, and PGE(2) production and are supportive of the further investigation of the therapeutic potential of 1 to control inflammatory pain.
dc.formatapplication/pdf
dc.languageeng
dc.rightsopen access
dc.subjectAnalgésicos/farmacologia
dc.subjectDor/quimioterapia
dc.subjectUmbeliferonas/farmacologia
dc.subjectAnalgésicos/química
dc.subjectAnalgésicos/metabolismo
dc.subjectAnalgésicos/uso terapêutico
dc.subjectAnimais
dc.subjectBrasil
dc.subjectDinoprostona/farmacologia
dc.subjectEdema/induzido quimicamente
dc.subjectEdema/quimioterapia
dc.subjectAdjuvante de Freund/farmacologia
dc.subjectCamundongos
dc.subjectModelos Animais
dc.subjectEstrutura Molecular
dc.subjectNeutrófilos/efeitos de drogas
dc.subjectNeutrófilos/fisiologia
dc.subjectDor/induzido quimicamente
dc.subjectMedição da Dor
dc.subjectFator de Necrose Tumoral alfa/farmacologia
dc.subjectUmbeliferonas/química
dc.subjectUmbeliferonas/uso terapêutico
dc.titleMechanisms involved in the antinociceptive effects of 7-hydroxycoumarin.
dc.typeArticle


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