Aotus infulatus Monkey is Susceptible to Plasmodium falciparum Infection and May Constitute an Alternative Experimental Model for Malaria

dc.creatorCarvalho, Leonardo J. M .
dc.creatorOliveira, Salma G.
dc.creatorAlves, Francisco A.
dc.creatorBrígido, Maria C. O .
dc.creatorMuniz, José A. P. C.
dc.creatorRibeiro, Claudio Tadeu Daniel
dc.date2020-10-19T18:09:03Z
dc.date2020-10-19T18:09:03Z
dc.date2000
dc.date.accessioned2023-09-26T23:33:30Z
dc.date.available2023-09-26T23:33:30Z
dc.identifierCARVALHO, Lonardo J. M. et al. Aotus infulatus Monkey is Susceptible to Plasmodium falciparum Infection and May Constitute an Alternative Experimental Model for Malaria. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 95, n. 3, p. 363-365, May/June 2000.
dc.identifier0074-0276
dc.identifierhttps://www.arca.fiocruz.br/handle/icict/44063
dc.identifier10.1590/S0074-02762000000300011
dc.identifier1678-8060
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8891859
dc.descriptionAotus is one of the WHO-recommended primate models for studies in malaria, and several species can be infected with Plasmodium falciparum or P. vivax. Here we describe the successful infection of the species A. infulatus from eastern Amazon with blood stages of P. falciparum. Both intact and splenectomized animals were susceptible to infection; the intact ones were able to keep parasitemias at lower levels for several days, but developed complications such as severe anemia; splenectomized monkeys developed higher parasitemias but no major complications. We conclude that A. infulatus is susceptible to P. falciparum infection and may represent an alternative model for studies in malaria.
dc.formatapplication/pdf
dc.languageeng
dc.publisherFundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.rightsopen access
dc.subjectAotus infulatus
dc.subjectPlasmodium falciparum
dc.subjectMalária
dc.subjectModelo primata
dc.subjectAotus infulatus
dc.subjectPlasmodium falciparum
dc.subjectMalaria
dc.subjectPrimate model
dc.titleAotus infulatus Monkey is Susceptible to Plasmodium falciparum Infection and May Constitute an Alternative Experimental Model for Malaria
dc.typeArticle


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